The reigning champions lead Group E on goal difference from Shakhtar, and the victors will take a huge step towards qualifying for the knockout phase even at this early stage.
Shakhtar, the 2009 UEFA Cup winners, seek their second victory of the campaign after beating Nordsjaelland of the Netherlands 2-0 in their opener last month.
Asked if Shakhtar had matured sufficiently as a team to beat sides like Chelsea, the 67-year-old Lucescu replied: “Yes, we’ve reached that level.
“We are the kind of team that can outplay such clubs,” he told the club’s web site.
Despite equating the quality of his side with that of the four-time English champions, Lucescu still said it was an honour to welcome a club of Chelsea’s standing to the Donbass Arena.
“For my players it’s big motivation and ambitions, for our supporters it is pride to receive such a club at our home arena, and for our club it’s fantastic, a big pleasure.”