The 1st Test ended in a draw after regular rain interruptions.
Abid Ali scored his maiden Test hundred in the 1st Test in Rawalpindi and will be looking to carry on the form.
Azhar Ali scored only 62 runs in four innings in Australia and 59 runs in six innings in South Africa earlier this year.
Test cricket returned to Pakistan after 10 years, post the terrorist attack on their team bus in Lahore in 2009.
Pakistan are currently sixth in the ICC Test Championship points table with 20 points while Sri Lankan are in third place with 80 points.
Last 5 Head To Head
Venue Details and Pitch Report
19 Dec, 10:30 AM IST
National Stadium, Karachi
Bruce Oxenford, Joel Wilson
Pakistan look the stronger of the two participating teams. Both teams played well in the rain-interrupted 1st Test with Babar Azam, Abid Ali and Dhananjaya de Silva scoring their respective hundreds. But Pakistan will be expecting more from their talented young bowling line-up who have shown potential in patches.