UFC Fight Night: Santos vs. Ankalaev is a mixed martial arts event produced by the Ultimate Fighting Championship that will take place on March 12, 2022, at UFC Apex facility in Enterprise, Nevada, part of the Las Vegas Metropolitan Area, United States.
UFC Fight Night: Santos vs. Ankalaev Main Card
| Weight Class | Fight | Method | Round | Results |
| Light Heavyweight | Thiago Santos vs. Magomed Ankalaev | Decision | R5 (05:00) | Magomed Ankalaev def. Thiago Santos |
| Bantamweight | Marlon Moraes vs. Song Yadong | KO/TKO | R1 (02:06) | Song Yadong def. Marlon Moraes |
| Featherweight | Sodiq Yusuff vs. Alex Caceres | Decision | R3 (05:00) | Sodiq Yusuff def. Alex Caceres |
| Light Heavyweight | Khalil Rountree vs. Karl Roberson | KO/TKO | R2 (00:25) | Khalil Rountree def. Karl Roberson |
| Lightweight | Drew Dober vs. Terrance McKinney | KO/TKO | R1 (03:17) | Drew Dober def. Terrance McKinney |
| Middleweight | Alex Pereira vs. Bruno Silva | Decision | R3 (05:00) | Alex Pereira def. Bruno Silva |
UFC Fight Night: Santos vs. Ankalaev Preliminary Card
| Weight Class | Fight | Method | Round | Results |
| Welterweight | Matthew Semelsberger vs. AJ Fletcher | Decision | R3 (05:00) | Matthew Semelsberger def. AJ Fletcher |
| Women Flyweight | JJ Aldrich vs. Gillian Robertson | Decision | R3 (05:00) | JJ Aldrich def. Gillian Robertson |
| Bantamweight | Trevin Jones vs. Javid Basharat | Decision | R3 (05:00) | Javid Basharat def. Trevin Jones |
| Featherweight | Damon Jackson vs. Kamuela Kirk | Submission | R2 (04:42) | Damon Jackson def. Kamuela Kirk |
| Women Flyweight | Sabina Mazo vs. Miranda Maverick | Submission | R2 (02:15) | Miranda Maverick def. Sabina Mazo |
| Middleweight | Dalcha Lungiambbula vs. Cody Brundage | Submission | R1 (03:41) | Cody Brundage def. Dalcha Lungiambbula |
| Bantamweight | Kris Moutinho vs. Guido Cannetti | KO/TKO | R1 (02:07) | Guido Cannetti def. Kris Moutinho |
| Light Heavyweight | Tafon Nchukwi vs. Azamat Murzakanov | KO/TKO | R3 (00:44) | Azamat Murzakanov def. Tafon Nchukwi |
