UFC Vegas 21: Edwards vs Muhammad was a mixed martial arts event produced by the Ultimate Fighting Championship that took place on March 13, 2021 at the UFC APEX, Las Vegas United States.
UFC Vegas 21 Fight Card and Results
Main Fight Card
| Weight Class | Fight Card | Method | Round | Results |
| Welterweight | Leon Edwards vs. Belal Muhammad | Decision | R2 00:18 | Draw |
| Light Heavyweight | Misha Cirkunov vs. Ryan Spann | KO/TKO | R1 01:11 | Ryan Spann def. Misha Cirkunov |
| Featherweight | Dan Ige vs. Gavin Tucker | KO/TKO | R1 00:22 | Dan Ige def. Gavin Tucker |
| Bantamweight | Jonathan Martinez vs. Davey Grant | KO/TKO | R2 03:03 | Davey Grant def. Jonathan Martinez |
| Flyweight | Manel Kape vs. Matheus Nicolau | Decision | R3 05:00 | Matheus Nicolau def. Manel Kape |
| Middleweight | Eryk Anders vs. Darren Stewart | Decision | R1 04:37 | Draw |
Preliminary Card
| Weight Class | Fight Card | Method | Round | Results |
| Women Strawweight | Angela Hill vs. Ashley Yoder | Decision | R3 05:00 | Angela Hill def. Ashley Yoder |
| Featherweight | Charles Jourdain vs. Marcelo Rojo | KO/TKO | R3 04:31 | Charles Jourdain def. Marcelo Rojo |
| Bantamweight | Rani Yahya vs. Ray Rodriguez | Submission | R2 03:09 | Rani Yahya def. Ray Rodriguez |
| Lightweight | Nasrat Haqparast vs. Rafa Garcia | Decision | R3 05:00 | Nasrat Haqparast def. Rafa Garcia |
| Women Flyweight | Cortney Casey vs. JJ Aldrich | Decision | R3 05:00 | JJ Aldrich def. Cortney Casey |
| Women Strawweight | Gloria de Paula vs. Jinh Yu Frey | Decision | R3 05:00 | Jinh Yu Frey def. Gloria de Paula |
| Welterweight | Matthew Semelsberger vs. Jason Witt | KO/TKO | R1 00:16 | Matthew Semelsberger def. Jason Witt |
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