Mexican Open 2022 Results - Day 6, 26th Feb
| Player 1 | Player 2 | Score |
| Rafael Nadal | Cameron Norrie | 6-4 6-4 |
Mexican Open 2022 Results - Day 5, 25th Feb
| Player 1 | Player 2 | Score |
| Rafael Nadal | Daniil Medvedev | 6-3 6-3 |
| Cameron Norrie | Stefanos Tsitsipas | 6-4 6-4 |
Mexican Open 2022 Results - Day 1, 21st Feb
| Player 1 | Player 2 | Score |
| Alexander Zverev | Jenson Brooksby | 3-6 7-6 6-2 |
| Taylor Fritz | Adrian Mannarino | 6-3 6-3 |
| Pablo Carreno Busta | Oscar Otte | 6-2 6-4 |
| Peter Gojowczyk | Brandon Nakashima | 6-4 6-4 |
| John Isner | Fernando Verdasco | 7-5 6-7 7-6 |
| Stefan Kozlov | Grigor Dimitrov | 7-6 5-7 6-3 |
| Dusan Lajovic | Sebastian Korda | 6-4 4-6 7-5 |
Mexican Open 2022 Results - Day 2, 22nd Feb
| Player 1 | Player 2 | Score |
| Daniil Medvedev | Benoit Paire | 6-3 6-4 |
| Rafael Nadal | Denis Kudla | 6-3 6-2 |
| Stefanos Tsitsipas | Laslo Djere | 7-6 7-6 |
| Tommy Paul | Matteo Berrettini | 4-6 5-1 |
| Cameron Norrie | Daniel Altmaier | 7-6 6-2 |
| J.J. Wolf | Lorenzo Sonego | 3-6 7-6 6-2 |
| Yoshihito Nishioka | Feliciano Lopez | 2-6 6-0 6-4 |
| Pablo Andujar | Alex Hernandez | 6-0 6-1 |
| Juan Sebastian Cabal / Robert Farah | Miguel Angel Reyes-Varela / Max Schnur | 5-7 6-2 10-4 |
| Hans Hach Verdugo / John Isner | Peter Gojowczyk / Oscar Otte | 6-3 2-6 1-6 1- 4 |
| Marcos Giron | John Millman | 7-6 2-0 (Retd) |
| Lloyd Glasspool / Harri Heliovaara | Marcelo Melo / Alexander Zverev | 6-2 4-6 10-6 |
Mexican Open 2022 Results - Day 3, 23rd Feb
| Player 1 | Player 2 | Score |
| Daniil Medvedev | Pablo Andujar | 6-1 6-2 |
| Peter Gojowczyk | Alexander Zverev | (W/O) |
| Stefanos Tsitsipas | J.J. Wolf | 6-1 6-0 |
| Rafael Nadal | Stefan Kozlov | 6-0 6-3 |
| Cameron Norrie | John Isner | 6-7 6-3 6-4 |
| Yoshihito Nishioka | Taylor Fritz | 3-6 6-4 6-2 |
| Marcos Giron | Pablo Carreno Busta | 6-7 6-4 7-6 |
| Tommy Paul | Dusan Lajovic | 7-6 2-6 7-5 |
Mexican Open 2022 Results - Day 4, 24th Feb
| Player 1 | Player 2 | Score |
| Cameron Norrie | Peter Gojowczyk | 6-1 6-0 |
| Daniil Medvedev | Yoshihito Nishioka | 6-2 6-3 |
| Stefanos Tsitsipas | Marcos Giron | 6-3 6-4 |
| Rafael Nadal | Tommy Paul | 6-0 7-6 |
