In the previous round, Nashville upset Toronto FC 1-0, thanks to an extra-time winner from Daniel Rios, who scored in the 108th minute of that game.
Nashville's reward for beating the MLS Eastern Conference's second-placed team is this tie against Columbus Crew, who finished third in the regular season.
In the previous round, Columbus Crew beat New York Red Bulls 3-2. Toronto FC's loss in the previous round means that Columbus Crew have a home tie for this conference semi-final.
Nashville are aiming to become the first expansion side since Chicago Fire in 1998 to reach a conference final.
That year, Fire actually went on to win the MLS Cup. If Nashville manage a repeat of that, it would certainly be a miraculous achievement.
Columbus Crew vs Nashville SC Head-to-Head
These two teams met each other only once in the regular season in a game that Columbus Crew won 2-0 at home in September. Pedro Santos and Gyasi Zardes scored the goals for Crew in that match.
Columbus Crew form guide: W-W-L-W-L
Nashville SC form guide: W-W-W-L-D
Columbus Crew vs Nashville SC Team News
Defender Vito Wormgoor is the only Columbus Crew player who will not be available for this game due to injury.
Injured: Vito Wormgoor
Abu Danladi is not expected to feature in this contest for Nashville SC. Neither is Anibal Godoy, who picked up an injury during the playoff play-in clash against Inter Miami CF.
Injuries: Anibal Godoy, Abu Danladi
Columbus Crew vs Nashville SC Predicted Lineups
Columbus Predicted XI (4-2-3-1): Andrew Tarbell; Harrison Afful, Jonathan Mensah, Josh Williams, Milton Valenzuela; Darlington Nagbe, Artur; Derrick Etienne, Lucas Zelarayan, Pedro Santos; Gyasi Zardes
Nashville SC (4-2-3-1): Joe Willis; Alistair Johnston, David Romney, Walker Zimmerman, Daniel Lovitz; Dax McCarthy, Brian Anunga; Alex Muyl, Hany Mukhtar Randall Leal; Jhonder Cadiz
Columbus Crew vs Nashville SC Prediction
Nashville will definitely come into this game on a high, after a sensational victory over the much-favored Toronto FC in the last round.
But we are predicting that this will be a bridge too far in a historic playoff run for Nashville, with a narrow Columbus Crew victory the most likely outcome.
Prediction: Columbus Crew 1-0 Nashville SCPublished 29 Nov 2020, 02:38 IST