The hosts suffered a 3-1 defeat away to Colorado Rapids last Saturday, with all four goals coming in an action-packed first half.
Vancouver Whitecaps were also on the wrong end of a debilitating defeat. Alan Pulido starred with a brace to give Sporting Kansas City a 3-0 victory on home turf.
Just one point separates the two sides on the table and they will each be seeking three points to boost their chances of making the playoffs.
Houston Dynamo are slightly better off in sixth place, having garnered eight points from six matches so far. Whitecaps are two places and one point below on the Western Conference table.
Houston Dynamo vs Vancouver Whitecaps Head-to-Head
This will be the 16th meeting between the sides and Vancouver Whitecaps have the marginally better record.
The Canadian outfit have eight wins to their name, while Houston Dynamo were victorious in five previous matches. Three games have been drawn between the two sides.
Their most recent meeting came in September 2019 when second half goals from In-Beom Hwang and Freddie Montero helped Vancouver Whitecaps pick up a 2-1 victory on home turf.
The two teams have each picked up two wins from the six league matches they have played so far.
Houston Dynamo form guide: L-W-D-D-L
Vancouver Whitecaps form guide: L-L-W-L-D
Houston Dynamo vs Vancouver Whitecaps Team News
The hosts have two players ruled out by injuries. Forward Tyler Pasher (abdominal) and defenders Ethan Bartlow and Sam Junqua are unavailable for selection due to respective concussions.
There are no suspension concerns for the Orange Crush.
Injuries: Ethan Bartlow, Tyler Pasher, Sam Junqua
Only defender Ali Adnan is unavailable for personal issues. There are no suspension worries for coach Marc Dos Santos.
Unavailable: Ali Adnan
Houston Dynamo vs Vancouver Whitecaps Predicted XI
Houston Dynamo Predicted XI (4-3-3): Marko Maric (GK); Maynor Figueroa, Tim Parker, Boniek Garcia; Adam Lundqvist, Derrick Jones, Joe Corona, Memo Rodriguez; Christian Ramirez, Fafa Picault, Niccolo Lemoine
Vancouver Whitecaps Predicted XI (4-4-2): Maxime Crepeau (GK); Cristian Gutierrez, Derek Cornelius, Ranko Veselinovic, Jakob Nerwinski; Deiber Caicedo, Caio Alexandre, Janio Bikel, Ryan Raposo; Cristian Dajome, Lucas Cavallini
Houston Dynamo vs Vancouver Whitecaps Prediction
Games involving the two sides have been largely compact and cagey affairs and that trend could be set to continue.
However, the hosts have been slightly more assertive and we are predicting a narrow victory for Houston Dynamo.
Prediction: Houston Dynamo 1-0 Vancouver Whitecaps