Notre Dame Fighting Irish vs. USC Trojans Prediction, Odds, Lines, Spreads, and Picks- November 26 | 2022 NCAA Football Season

Notre Dame Fighting Irish are on a five-game winning streak, including impressive victories over Syracuse Orange and Clemson Tigers. They come into the Coliseum to take on a team on a mission, the USC Trojans. The Notre Dame/USC rivalry has been the subject of many college football history books, and they are set to write yet another chapter this year. Notre Dame have turned their season around with a ferocious defense and commendable grit, while USC continue to embark on a season that could end with a trip to the National Title game. A contrast in styles, will Notre Dame or USC be victorious in this one?

The betting odds and predictions are below:

TEAMS	LINES	OVER/UNDER	MONEY LINE
Notre Dame Fighting Irish	+4.5 (-110)	O 64 (-110)	+155
USC Trojans	-4.5 (-110)	U 64 (+110)	-180

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Notre Dame Fighting Irish vs. USC Trojans Details

Fixture: Notre Dame Fighting Irish @ USC Trojans

Date and Time: Saturday, November 26, 7:30 PM ET

Venue: Los Angeles Memorial Coliseum, Los Angeles, California

Notre Dame Fighting Irish vs. USC Trojans Best Pick

Caleb Williams is making a compelling case of being the best QB in college football. Williams has been that sensational coming down the stretch. USC Trojans withstood a challenge from the UCLA Bruins and were able to walk away victorious. The challenge this weekend is substantially different. The UCLA game had "shoot-out" written all over it, where defensive stops were few and far between. Notre Dame have been playing exceptionally well lately and bring a defensive prowess that USC have not seen in 2022. Expect the Trojans to grind out longer dives, with the running game being a big part of the game plan. We don't doubt the talent or capabilities of Caleb Williams, but this will be a different ball game. Take the Under on the passing yards.

Caleb Williams, QB USC Trojans, 320.5 Passing Yards: Under

Notre Dame Fighting Irish vs. USC Trojans Final Prediction

What a fascinating match-up we have to end the regular season. Notre Dame Fighting Irish are playing as well as any team in the nation. USC Trojans have answered all questions and continue their Trojan march to a potential National Championship Final Four bid. Notre Dame might slow the Trojans' offense down significantly, but the Fighting Irish don't have enough offensive firepower to stick with Caleb Williams and USC for four quarters. Watch out for the Trojans to pull away late to cap off a tremendous regular season. Take USC to cover.

USC Trojans -4.5 (-110)

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