Manchester United and Cristiano Ronaldo were handed a shock 4-2 defeat by Leicester City in the Premier League on Saturday. The visitors opened the scoring at the King Power Stadium courtesy of an excellent strike from outside the box by Mason Greenwood. Despite conceding inside the first 20 minutes, Leicester responded by finding the equalizer in the 31st minute.Youri Tielemans curled an outrageous finish from just outside the box after Manchester United captain Harry Maguire allowed Kelechi Iheanacho to rob him off the ball.While the two teams entered the half-time interval level pegging, it was Leicester who started the second forty-five brightly. Tielemans came close to scoring again, but his shot was pushed onto the woodwork by David De Gea. The Manchester United goalkeeper then produced an excellent save from Patson Daka.Cristiano Ronaldo failed to make an impact for Manchester UnitedMeanwhile, Cristiano Ronaldo cut a peripheral figure at the other end of the pitch. The Portuguese was adjudged offside in his attempt to find the back of the net before Leicester took the lead again. Caglar Soyuncu pounced on a loose ball from a corner kick to stab home the equalizer after Daka had forced another good save from De Gea.Marcus Rashford restored parity for Manchester United after a stunning counter-attack but the joy was short-lived. Cristiano Ronaldo and company were shell-shocked as Leicester responded instantly from the restart. Ayoze Perez's cut-back was smashed into the top corner by Jamie Vardy to pile misery on Manchester United.Later, in second-half stoppage time, Daka scored his first Premier League goal to complete the rout. Cristiano Ronaldo cut a frustrated figure like many of his team-mates and witnessed Manchester United's remarkable run on the road come to an end.In the wake of the harrowing defeat suffered by Manchester United, Twitter erupted with reactions from across the globe. Here are some of the best of the lot as Cristiano Ronaldo and company endured a forgettable outing:Premier League@premierleagueFULL-TIME Leicester 4-2 Man UtdWhat a match! @LCFC end Man Utd's 29-match unbeaten run away from home in the #PL #LEIMUN9:26 AM · Oct 16, 20211229269FULL-TIME Leicester 4-2 Man UtdWhat a match! @LCFC end Man Utd's 29-match unbeaten run away from home in the #PL #LEIMUN https://t.co/J6A3ag7AaBSquawka Football@SquawkaLeicester have recorded back-to-back Premier League wins over Manchester United for the first time in their history:✅ 2-1✅ 4-2 And they've broken Manchester United's 29 game unbeaten away record in the process. 🦊9:26 AM · Oct 16, 202114443Leicester have recorded back-to-back Premier League wins over Manchester United for the first time in their history:✅ 2-1✅ 4-2 And they've broken Manchester United's 29 game unbeaten away record in the process. 🦊 https://t.co/86QSUIomZeRedReveal@RedRevealFTLeicester City 4-2 Manchester United🔴 Mason Greenwood🔵 Youri Tielemans🔵 Caglar Soyuncu🔴 Marcus Rashford🔵 Jamie Vardy🔵 Patson Daka🅰️ Bruno Fernandes🅰️ Victor LindelofJust getting worse and worse. Could easily have been 10. #mufc #LEIMUN9:26 AM · Oct 16, 20211FTLeicester City 4-2 Manchester United🔴 Mason Greenwood🔵 Youri Tielemans🔵 Caglar Soyuncu🔴 Marcus Rashford🔵 Jamie Vardy🔵 Patson Daka🅰️ Bruno Fernandes🅰️ Victor LindelofJust getting worse and worse. Could easily have been 10. #mufc #LEIMUNLeesharn Rose@ChelsLee86Hol up where Ronaldo at??? How yall losing with him 😂. I mean no goal registered.. Ah nevermind you're playing against Leicester not Lithuania or Luxembourg 😂😂😂#LEIMUN9:22 AM · Oct 16, 2021131Hol up where Ronaldo at??? How yall losing with him 😂. I mean no goal registered.. Ah nevermind you're playing against Leicester not Lithuania or Luxembourg 😂😂😂#LEIMUNDave《MUFC》🔴@D4VEutdThis was Leicester without Ndidi… would’ve probably ended 4-0 if Ndidi was on the field#LEIMUN9:26 AM · Oct 16, 2021This was Leicester without Ndidi… would’ve probably ended 4-0 if Ndidi was on the field#LEIMUN◢◤Athu◢◤🏆💙@Athu_BluesBest defence #LEIMUN9:26 AM · Oct 16, 2021Best defence #LEIMUN https://t.co/VRZRaiwAkILwazi Msomi@RealLwaziMsomiBeing a Manchester United fan has done a Number on my mental health I honestly don't know how long I can keep this up. #OleOut #MUFC #LEIMUN9:26 AM · Oct 16, 2021Being a Manchester United fan has done a Number on my mental health I honestly don't know how long I can keep this up. #OleOut #MUFC #LEIMUN https://t.co/pzvw0fBomQFootballfan23578@Footbal82765042United fans seeing they have to play Liverpool, Chelsea Arsenal, City and Tottenham next. #LEIMUN9:26 AM · Oct 16, 2021United fans seeing they have to play Liverpool, Chelsea Arsenal, City and Tottenham next. #LEIMUN https://t.co/lazsZEchmuSamuel Ilesanmi@ilesanmisamuel_Fans: Ole at the wheel!The wheel:#OleOut #MUFC #LEIMUN9:26 AM · Oct 16, 2021Fans: Ole at the wheel!The wheel:#OleOut #MUFC #LEIMUN https://t.co/IniZTUkpsuSegun_thebook@SSnetwoorkForget Maguire! Pogba, Ronaldo and Bruno Fernandes were VERY VERY POOR!!!#LEIMUN9:28 AM · Oct 16, 2021Forget Maguire! Pogba, Ronaldo and Bruno Fernandes were VERY VERY POOR!!!#LEIMUNSimon Stone@sistoney67End of @ManUtd long unbeaten away run. One point from three games. Liverpool next.9:27 AM · Oct 16, 202121610End of @ManUtd long unbeaten away run. One point from three games. Liverpool next.Duncan Alexander@oilysailorMan Utd's first PL away defeat in the Disney+ era9:25 AM · Oct 16, 202115319Man Utd's first PL away defeat in the Disney+ eraZach Lowy@ZachLowyWhat do Manchester United players do in training every week? Red Light Green Light? Tug of War? Sugar Honeycomb? It definitely isn’t football.9:24 AM · Oct 16, 2021576243What do Manchester United players do in training every week? Red Light Green Light? Tug of War? Sugar Honeycomb? It definitely isn’t football.Matthew Doyle@MattDoyle76In other EPL news, Cristiano has made Man U worse & much easier to play against for top clubs, and Ole appears terrified to sub him off.9:27 AM · Oct 16, 2021336In other EPL news, Cristiano has made Man U worse & much easier to play against for top clubs, and Ole appears terrified to sub him off.Ian Ladyman@Ian_Ladyman_DMRonaldo heading off the field. Told by OGS to acknowledge away fans. Walks ten yards towards them. Claps. Walks off. Not his best afternoon.9:29 AM · Oct 16, 2021121Ronaldo heading off the field. Told by OGS to acknowledge away fans. Walks ten yards towards them. Claps. Walks off. Not his best afternoon.Abid Orakzai@BeingAbid_Ronaldo leaving Man united this summer.🤣😂#MUFC #LEIMUN9:31 AM · Oct 16, 2021Ronaldo leaving Man united this summer.🤣😂#MUFC #LEIMUN https://t.co/bX9JNR97LgZachrie 🇰🇪❤🇺🇸@Zachrie14529311@ManUtd What does Ronaldo over to man united apart from moments 🤔 he really declined us9:31 AM · Oct 16, 2021@ManUtd What does Ronaldo over to man united apart from moments 🤔 he really declined usAbbas 🈵@ItzzSonuuuuuJamie Vardy making Ronaldo regret that he came to united 😭😭😭9:31 AM · Oct 16, 2021Jamie Vardy making Ronaldo regret that he came to united 😭😭😭siya | viva ronaldo@siacantwaitodieI'll only watch Madrid from now on. Can't force myself to watch United anymore.9:31 AM · Oct 16, 2021I'll only watch Madrid from now on. Can't force myself to watch United anymore.TY Alu@realmctyRonaldo is just an extra load to this Manchester United side..9:30 AM · Oct 16, 2021Ronaldo is just an extra load to this Manchester United side..Mia@CitehLeahPeople thought United would be title contenders with Ronaldo 😭😭😭😭😭9:30 AM · Oct 16, 2021People thought United would be title contenders with Ronaldo 😭😭😭😭😭Samuel Temitope@samuelt18956407Manchester United were 29 matches unbeaten away from home before the signed Ronaldo. The rest is history? Is this your Balon d'or deserved player? 😅 😅9:30 AM · Oct 16, 2021Manchester United were 29 matches unbeaten away from home before the signed Ronaldo. The rest is history? Is this your Balon d'or deserved player? 😅 😅 https://t.co/g9HoDtFnseMoha Jr🇰🇪@DiscipyMayManchester United lost, Ronaldo included, and the whole world is happy 😁9:32 AM · Oct 16, 20212Manchester United lost, Ronaldo included, and the whole world is happy 😁harry@poshboyhBuying Ronaldo ruined United, he’s finished9:33 AM · Oct 16, 20211Buying Ronaldo ruined United, he’s finishedStephen Morrison@ItScubaSteveRemember that time United signed Ronaldo and their fans and half the pundits in England thought they were gonna win the league 😂9:33 AM · Oct 16, 2021Remember that time United signed Ronaldo and their fans and half the pundits in England thought they were gonna win the league 😂