PANS Syndrome: Understanding the Link with OCD

PANS syndrome (Pediatric Acute-onset Neuropsychiatric Syndrome) is a term used to describe a group of conditions that involve sudden and dramatic onset (Naomi Shi/ Pexels)
PANS syndrome (Pediatric Acute-onset Neuropsychiatric Syndrome) is a term used to describe a group of conditions that involve sudden and dramatic onset (Naomi Shi/ Pexels)

PANS syndrome (Pediatric Acute-onset Neuropsychiatric Syndrome) is a term used to describe a group of conditions that involve sudden and dramatic onset.

One subtype of PANS is known as PANDAS (Pediatric Autoimmune Neuropsychiatric Disorders Associated with Streptococcal Infections), which occurs after a streptococcal infection.


PANS syndrome: A New and Complex Diagnosis

(cottonbro studio/ Pexels)
(cottonbro studio/ Pexels)

PANS is a relatively new diagnosis, first introduced in 2012, that encompasses a range of neuropsychiatric conditions. PANS is characterized by a sudden onset of symptoms, which can be severe and debilitating.

It is thought to be caused by the immune system's response to an infection or other environmental trigger that leads to inflammation in the brain.

PANDAS is a subtype of PANS that occurs after a streptococcal infection and is characterized by the immune system producing antibodies that mistakenly attack the basal ganglia, resulting in a range of neuropsychiatric symptoms.


Symptoms of PANS

PANS symptoms can vary widely from person to person and can include anxiety, depression, irritability, aggression, tics, sensory sensitivities, and obsessive-compulsive behaviors.

These symptoms can be sudden in onset, often causing significant distress and impairment in daily functioning. One of the most common symptoms associated with PANS is OCD, which is characterized by intrusive thoughts or obsessions that lead to repetitive behaviors or compulsions.


The link Between PANS and OCD

While not everyone with PANS syndrome or PANDAS will experience OCD symptoms, there is a clear link between these conditions. In fact, PANDAS was originally coined as a subtype of OCD due to the high prevalence of OCD symptoms in those with the condition.

The onset of OCD symptoms in PANS can be sudden and severe, and may not be related to any previous history of OCD. This can make diagnosis and treatment more challenging, as it may be difficult to distinguish between PANS-related OCD and other forms of OCD.

While not everyone with PANS syndrome or PANDAS will experience OCD symptoms(Jessica West/ Pexels)
While not everyone with PANS syndrome or PANDAS will experience OCD symptoms(Jessica West/ Pexels)

Diagnosis and Treatment of PANS

If you or one of your loved ones is experiencing a sudden onset of neuropsychiatric symptoms, it is important to seek medical evaluation to determine if PANS syndrome or PANDAS may be the underlying cause.

Diagnosis of PANS syndrome can be challenging, as there is no specific test or biomarker for the condition. Diagnosis typically involves ruling out other potential causes of the symptoms, such as infections or autoimmune disorders.

Treatment for PANS syndrome typically involves addressing the underlying inflammation through the use of anti-inflammatory medications, antibiotics, or other immune-modulating therapies.

Therapy and support for the neuropsychiatric symptoms associated with PANS may also be helpful. This can include cognitive behavioral therapy, family therapy, and support groups.


PANS is a complex condition that can be challenging to diagnose and treat. While not everyone with PANS or PANDAS will experience OCD symptoms, there is a clear link between these conditions.

If you or a loved one is experiencing a sudden onset of neuropsychiatric symptoms, it is important to seek medical evaluation to determine if PANS or PANDAS may be the underlying cause.

Early intervention and treatment can help improve outcomes and quality of life for those affected by these conditions.

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