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#4 Karo Parisyan vs Matt Hughes - UFC 56
In one of the most unfortunate incidents in UFC history, Karo Parisyan was facing a shot at the welterweight title held by Matt Hughes before a hamstring injury forced him out of the bout.
From March 2001 to April 2006, Parisyan lost only one of his 10 fights, that too to a certain Georges St-Pierre. He clinched the WEC welterweight title and seemed set to repeat the feat in the UFC before the injury. 'The Heat' was replaced by Joe Riggs and would never come genuinely close to a title shot again.
Parisyan was beaten by Diego Sanchez, Thiago Alves and Dennis Hallman in his last seven UFC fights, apart from a win that was overturned to a no-contest because he tested positive for banned painkillers. He fought under a variety of banners without much success after leaving the UFC, having missed out on the biggest opportunity of his fighting career.
#3 Rafael dos Anjos vs Conor McGregor - UFC 196
There's no love lost between Conor McGregor and Rafael dos Anjos even today. The two former UFC lightweight champions, who were scheduled to meet at UFC 196 before Dos Anjos had to pull out with a foot injury, continue to take potshots at each other on social media.
McGregor, the featherweight champion at the time, was booked to face another Brazilian belt holder in Dos Anjos. After RDA pulled out, 'The Notorious' took on Nate Diaz on short notice.
While the Diaz vs McGregor saga was going on, Dos Anjos lost the title to Eddie Alvarez, whom the Irishman would beat at UFC 205 to become the first simultaneous two-division champion in UFC history.
How would Dos Anjos have fared against McGregor? It's tough to say, but it's perhaps possible that he would've given a better account of himself than Alvarez did.
And despite facing off against several high-quality fighters after that and fighting for the interim UFC welterweight title, RDA certainly lost what would've been the pinnacle of his MMA career - both financially and otherwise.
