Cyborg had been the entire featherweight division throughout her 17 month reign, as the company struggled to find worthy opposition for her in that weight class.
It saw names such as Tonya Evinger and Holly Holm move down in weight to face her, and that is exactly what reigning Bantamweight Champion, Nunes, did too.
However, Nunes did something that neither Evinger or Holm could, she defeated the champion. Not only that, but she crushed Cyborg in less than a minute to become a dual champion, with slick combinations to knock her out.
Cyborg is left looking at whether she has an MMA future.
But in victory, what next for Nunes?
The Brazilian has secured her legacy already as the first female in UFC history to become a dual champion, and only the third fighter in the promotion's 25 year history to do so after Conor McGregor and Daniel Cormier.
She has ended the career of UFC Hall of Famer, Ronda Rousey, defeated names such as Miesha Tate & Valentino Shevchenko (twice), and now has taken out one of the UFC's top figureheads - Cyborg.
It is difficult to see Nunes defending the Featherweight Championship. With her size and weight, she would likely be an even more dominant champion than Cyborg. For Nunes to be tested inside the Octagon, she has to fight at Bantamweight.
The future of the Featherweight belt may be up in the air, but one fight at Bantamweight that could be very interesting is a collision with former champion, Holly Holm.
Germaine de Randamie is another option, and another marquee name the Brazilian has yet to face in her career. No matter what her next move is, after this win, the world will be watching Nunes.