Bills vs. Lions: Who Will Win? Betting Prediction, Odds, Lines, and Picks for NFL Games Today - November 24

Buffalo Bills (7-3), second in the AFC East, will face the Detroit Lions (4-6), who are in second place in the NFC North. The teams will be squaring off on Thursday afternoon to kick off the Week 12 NFL action.

Buffalo is coming off a 31-23 neutral site game on Sunday against the Cleveland Browns on Sunday.

The game was relocated to Ford Field as there was a massive snowstorm in Buffalo which forced the game to be moved to a different stadium. Detroit is on a three-game winning streak and is coming off a 31-18 road victory over the New York Giants on Sunday.

Bills vs Lions: Match Details

Fixture: Bills @ Lions

Date & Time: November 24, 2022 at 12:30pm EST

Venue: Ford Field, Detroit

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Buffalo Bills vs. Detroit Lions: Betting Odds

Team	Moneyline	Spread	Over/Under
Buffalo Bills	-460	-9.5 (-110)	O 54 (-110)
Detroit Lions	+370	+9.5 (-110)	U 54 (-110)

Buffalo Bills vs. Detroit Lions Best Picks:

Stefon Diggs Over 90.5 Receiving Yards (-115)

People are going to be afraid of this wager since Diggs did not get many targets on Sunday, but Detroit's defense is not great.

He is averaging 105 receiving yards per game in his last five games and has achieved at least 10 targets in three of the last five games. There is not a cornerback on the Lions roster that can keep the ball out of Diggs' hands, so go with the over.

Jared Goff Under 1.5 Passing TDs (-145)

The passing game for the Detroit Lions are not their strength as he has thrown for just four passing touchdowns in his last six games. That makes it a lot tougher, especially against a tough Buffalo defense as they have only allowed 12 passing touchdowns throughout the course of the season.

Goff is going to need to throw some more as he has thrown 26 pass attempts in each of his previous three games so go with under on the passing touchdowns bet here.

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Buffalo Bills vs. Detroit Lions Prediction

This Buffalo defense is one of the best in the entire sport, but they are struggling to get stops lately as they are allowing 25.3 points in their previous three games. In comparison, Detroit is giving up 19 points per game in that three-game stretch.

The underdog has covered in four of the previous five games against one another, so go with the Detroit Lions to cover the spread and keep this game a lot closer than the spread shows.