Bills vs Patriots: Who Will Win? Prediction, Odds, Lines, Spread, and Picks - TNF Week 13

The Buffalo Bills head to New England to take on the Patriots for the first time this season. After the Thanksgiving football was given to fans last week, hopefully, this will be a strong follow-up.

The Patriots played on Thursday last week, and here they are again, hosting the division-leading Bills. At the moment, the Patriots are a game out of the New York Jets for a playoff spot. This is the first time in a long time -- if not ever -- that every AFC East team is bidding for a postseason spot.

After decades of the Patriots dominating a terrible division, the Bills and Dolphins are two of the best teams in the AFC, and the Patriots and Jets are no scrubs themselves.

Bills vs. Patriots Betting Odds

	Spread	Moneyline	Over/Under
Bills	-3.5 (-107)	-190	Over 43.5 (-110)
Pats	+3.5 (-107)	+160	Under 43.5 (-105)

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Bills vs. Patriots Match Details

Fixture: Buffalo Bills @ New England Patriots

Date & Time: Thursday, December 1, 2022 8:30 p.m. EST

Venue: Gillette Stadium, Foxborough, MA

Bills vs. Patriots Best Picks

It's Thursday Night Football, and it is almost an impulse at this point to bet the under. There are a few reasons for that; many believe the short rest combined with little preparation time coming into a Thursday game is to blame. But, be that as it may, that is not why the under is a smart move tonight.

The under would be advisable even if this game was being played on a Monday and both teams were coming off a bye. This will be a defense-heavy game.

Bettors never know what they will see with New England's offense, but they definitely won't see this much against this Buffalo team.

As for Josh Allen, Bill Belichick knows he needs to limit Buffalo's offensive output to give his team a chance. So Bettors should not expect high-flying numbers from the Reedley College kid.

Under 43.5 Points (-110)

Bills vs. Patriots Prediction

Buffalo has not been the juggernaut they were talked up to be this off-season. Instead, they have shown they have weaknesses and are absolutely beatable.

While the Patriots offense has been one of the worst in the league, Belichick's defense has kept this team in a position to make the playoffs.

Divisional games are their own beast, and bettors have to put so much more into consideration. Playing at home, three and a half points is far too many to be giving the Patriots. So while New England has not shown they are necessarily deserving of a moneyline bet, this is an easy spread to take.