Astros vs. Brewers: Game 1, prediction, odds, injuries and picks

The Houston Astros (17-16) are on the road to face the Milwaukee Brewers (17-18) for a three-game series. American Family Field in Milwaukee, Wisconsin, will host the matchup, with both teams looking to find some momentum.

The Astros suffered a humiliating series defeat at the hands of the Chicago White Sox and are third in the AL West, 3.0 games behind the leaders Seattle Mariners. On the other hand, the Brewers are also third in the NL Central and 4.0 games behind the leaders Chicago Cubs, the team that beat them in a three-game series over the weekend.

Astros vs. Brewers Game 1: Betting Odds & Weather

Date & Time: Monday, May 5th, 2025, 7:40 p.m. E.T

Money Line: Brewers -116

Over/Under: Over 8 runs

Weather: Party Cloudy, 66 °F, 11 mph wind, 5% chance of precipitation

Astros vs. Brewers Game 1: Injuries and Lineups

Injuries

Astros

Taylor Trammell: 10 Day IL (Calf),
Shawn Dubin: 15 Day IL (Shoulder),
Forrest Whitley: 15 Day IL (Knee),
J.P. France: 60 Day IL (Shoulder),
Pedro Leon: 10 Day IL (Knee),
Spencer Arrighetti: 15 Day IL (Thumb),
Cristian Javier: 60 Day IL (Elbow),
Luis Garcia: 60 Day IL (Elbow)

Brewers

Garrett Mitchell: 10 Day IL (Oblique),
Connor Thomas: 15 Day IL (Elbow),
Robert Gasser: 60 Day IL (Elbow),
Nestor Cortes: 60 Day IL (Elbow),
Blake Perkins: 60 Day IL (Shin),
D.L. Hall: 60 Day IL (Lat),
Brandon Woodruff: 15 Day IL (Shoulder),
Aaron Ashby: 15 Day IL (Oblique),
Aaron Civale: 15 Day IL (Hamstring),
Sal Frelick: day-to-day (Knee)

Projected Lineups

Astros

SS Jeremy Pena [R]
LF Jose Altuve [R]
DH Y. Alvarez [L]
1B C. Walker [R]
3B I. Paredes [R]
C Yainer Diaz [R]
RF Zach Dezenzo [R]
CF Jake Meyers [R]
2B B. Rodgers [R]

Brewers

CF J. Chourio [R]
2B Brice Turang [L]
C W. Contreras [R]
DH C. Yelich [L]
1B Rhys Hoskins [R]
RF Sal Frelick [L]
LF I. Collins [S]
SS Joey Ortiz [R]
3B Caleb Durbin [R]

Astros vs. Brewers Game 1: Prediction and Picks

The Astros will get a boost with Yordan Alvarez back in the lineup. Jeremy Pena is on a eight-game hit streak but power-hitting has been a concern for Houston with team highs of four home runs from Pena, Issac Paredes and Jose Altuve.

The Brewers' batting has mostly relied on Jackson Chourio who has 24 RBIs for the team this season. However, he is hitting at .095 in his last five games. Brice Turang is the other star in the lineup. He has 16 RBIs and is leading the team with a .315 average.

On the mound, Ronel Blanco for the Astros takes on Tobias Myers from the Brewers. Blanco has relatively more experience and has made a better start to the season with a 2-2 record.

Prediction: Brewers 5, Astros 4

Picks

Brewers -116

Over 8 Runs

About the author

Nikhil Parshy is a baseball and ice hockey journalist at Sportskeeda, and after starting out as a cricket reporter, he has been an analyst with SK since November 2022. His interest in the sports were piqued a few years back after watching highlights on YouTube and he has followed the game ever since.

The Chicago Cubs breaking the 108-year curse in 2016 to lift the World Series remains Nikhil's favorite baseball moment. Two-way phenom Shohei Ohtani has been his favorite player ever since he started following the game, while the LA Dodgers are his favorite team.

As a writer, Nikhil maintains a strong attention to detail and rigorously cross-checks information. He seeks to strike a balance in his writing such that the regular reader gains an insight into player profiles, while also keeping in mind that the non-regular reader is not put off by jargon and shallow analysis.

Nikhil is an avid public speaker, and when not writing about baseball, he regularly participates in debates and quizzes.

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Edited by Chaitanya Prakash

Astros vs. Brewers: Game 1, prediction, odds, injuries and picks - May 5, MLB 2025

Astros vs. Brewers Game 1: Betting Odds & Weather

Astros vs. Brewers Game 1: Injuries and Lineups

Injuries

Astros

Brewers

Projected Lineups

Astros

Brewers

Astros vs. Brewers Game 1: Prediction and Picks