Astros vs. Rangers: Game 3 prediction, lineup, odds, injuries, and picks - September 7, 2025

The Houston Astros rebounded with an impressive 11-0 shutout after the Texas Rangers took the series opener in 12 innings. This will be the last game in Texas, with each team taking 3 wins apiece. Rangers lead 5-4 so far.

Rangers (73-70) had a chance to cut the Astros' (78-65) lead to 2.0 games at the start of the series. But with Saturday's win, Houston has retained the 5.0-game gap, with the Seattle Mariners sandwiched between both teams with a 74-68 record.

Texas remains just outside the AL Wild Card spots.

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Astros vs. Rangers Game 3: Betting odds and weather

Time: 2:35 p.m. ET at Globe Life Field

Money Line: Astros -130, Rangers +110

Total Runs: Over/Under is 8.5 runs

Weather: In domed stadium, not applicable

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Astros vs. Rangers Game 3: Injuries and lineups

Injuries

Astros

• Spencer Arrighetti: 15 Day IL (Elbow),
• Bennett Sousa: 15 Day IL (Elbow),
• Josh Hader: 15 Day IL (Shoulder),
• Kaleb Ort: 15 Day IL (Elbow),
• Brandon Walter: 60 Day IL (Elbow),
• Ronel Blanco: 60 Day IL (Elbow),
• Zach Dezenzo: 60 Day IL (Hand),
• John Rooney: 60 Day IL (Concussion/nasal),
• Brendan Rodgers: 60 Day IL (Oblique),
• Isaac Paredes: 60 Day IL (Hamstring),
• Hayden Wesneski: 60 Day IL (Elbow),
• Pedro Leon: 60 Day IL (Knee)

Rangers

• Sam Haggerty: 10 Day IL (Oblique),
• Adolis Garcia: 10 Day IL (Quadricep),
• Marcus Semien: 10 Day IL (Foot),
• Corey Seager: 10 Day IL (Appendectomy),
• Nathan Eovaldi: 15 Day IL (Rotator cuff),
• Danny Coulombe: 15 Day IL (Shoulder),
• Cody Bradford: 60 Day IL (Elbow),
• Tyler Mahle: 60 Day IL (Shoulder),
• Jon Gray: 60 Day IL (Shoulder),
• Josh Sborz: 60 Day IL (Shoulder),
• Evan Carter: 60 Day IL (Wrist)

Expected Lineups

Astros

1. SS Jeremy Pena R
2. DH Y. Alvarez L
3. LF Jose Altuve R
4. 3B C. Correa R
5. 1B C. Walker R
6. C Yainer Diaz R
7. 2B Ramon Urias R
8. RF Cam Smith R
9. CF Jake Meyers R

Rangers

1. SS Josh Smith L
2. LF W. Langford R
3. DH Joc Pederson L
4. 1B Rowdy Tellez L
5. 3B Josh Jung R
6. C K. Higashioka R
7. 2B Cody Freeman R
8. RF A. Osuna L
9. CF M. Helman R

Astros vs. Rangers Game 3: Expert picks and prediction

Astros' Luis Garcia starts just his second game of the season. Facing him will be Patrick Corbin (7-9, 4.48 ERA), who has just one quality start since August, an 8.0 inning shutout against the Angels.

The Rangers' lineup will be concerned, having been shut out for the second time in 3 games. They have a .237 batting average this season. But a lot would be riding on their pitching staff, who have a collective 3.47 ERA, looking to come back after Saturday's blowout.

The Rangers are still without Corey Seager, their best at-bat. They would need Adolis Garcia and Wyatt Langford to fire. Astros' Jeremy Pena, Christian Walker and Jose Altuve lead their batting metrics.

Prediction: Rangers 5, Astros 4

Picks: Astros ML (-130), Over 8.5 runs