Blue Jays vs. Guardians: Game 1 prediction, odds, injuries, and picks

The Toronto Blue Jays and Cleveland Guardians are set to begin a three-game series on Tuesday night at Progressive Field. Both teams are right in the middle of the Wild Card race in the AL, putting extra pressure on this matchup.

Toronto comes into this series with a 41-36 record, while Cleveland is slightly behind them at 39-37. The odds for the series opener have been announced, and it's time to make some predictions.

Blue Jays vs. Guardians prediction

Bo Bichette, Toronto Blue Jays - Source: Imagn

Eric Lauer is going to be on the mound for the Toronto Blue Jays in this game, and he has gone 3-1 with a 2.29 ERA this season. The pitching has been carrying the Blue Jays, and Lauer will try to continue that trend.

Bo Bichette is having a big season at the plate for Toronto as he leads the team with 11 home runs and 48 RBIs. Bichette is going to need some help in this series, and the Blue Jays have some stars.

Logan Allen is going to be starting for the Cleveland Guardians, and he has been a solid starter this season. Allen has gone 5-4 with a 4.21 ERA this season, and he needs to slow down Bichette and the Blue Jays.

Jose Ramirez has been on a recent tear at the plate for the Guardians, and he now leads the team with 13 home runs and a .323 batting average. Look for this to be a great battle, but Toronto will win the series opener.

Prediction: Toronto Blue Jays 5, Cleveland Guardians 4

Blue Jays vs. Guardians odds

Money Line: Toronto Blue Jays -120, Cleveland Guardians EVEN

Run Spread: Blue Jays -1.5 (+140), Guardians +1.5 (-165)

Total Runs: Over 8.5 (-135), Under 8.5 (+115)

Blue Jays vs. Guardians injuries

Toronto Blue Jays injury report

Max Scherzer (RHP): 60-Day IL (Right thumb inflammation)

Daulton Varsho (OF): Late June or July (Left hamstring strain)

Yimi Garcia (RHP): 10-Day IL (Right shoulder impingement)

Bowden Francis (RHP): 15-Day IL (Right shoulder impingement)

Anthony Santander (OF): 10-Day IL (Left shoulder inflammation)

Alek Manoah (RHP): 60-Day IL (Right UCL surgery)

Ryan Burr (RHP): 60-Day IL (Right shoulder inflammation)

Ricky Tiedemann (LHP): Late 2025 (Tommy John surgery)

Cleveland Guardians injury report

Paul Sewald (RHP): 15-Day IL (Right posterior deltoid strain)

Trevor Stephan (RHP): 60-Day IL (Right UCL reconstruction surgery)

Erik Sabrowski (LHP): 60-Day IL (Left elbow inflammation)

Shane Bieber (RHP): 60-Day IL (Right UCL tear)

John Means (LHP): 60-Day IL (Left elbow UCL surgery)

Blue Jays vs. Guardians picks

Expect a very tight game in the series opener between these teams, but it will be the Toronto Blue Jays that escape with a victory.

Money Line: Toronto Blue Jays -120

Run Spread: Cleveland Guardians +1.5 (-165)

Total Runs: Over 8.5 (+115)

About the author

Ryan Burks is a baseball journalist at Sportskeeda with over 7 years of experience in the field, writing for publications such as Knup Sports. Ryan graduated from Elmhurst College in 2009 with a degree in Communications.

Ryan is a huge Chicago Cubs fan and enjoys their storied history and traditions. His favorite sporting moment was when the Cubs won the 2016 World Series, breaking a championship drought that dated back to 1908.

His favorite player was Ken Griffey Jr., as Ryan grew up during his prime and he was the coolest player in league history. Greg Maddux also deserves a mention, as he was truly amazing on the mound.

When not working or watching sports, Ryan coaches basketball and baseball, loves fishing, and spends time with his family.

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Edited by Victor R. Lopez M.

Blue Jays vs. Guardians: Game 1 prediction, odds, injuries, and picks - June 24, 2025