Cardinals vs. Guardians: Game 3 prediction, odds, injuries, and picks

The St. Louis Cardinals and Cleveland Guardians are set to wrap up a three-game series on Sunday afternoon. St. Louis is looking to complete the sweep after taking care of business in the first two games.

With the two straight wins, the Cardinals have improved to 46-38 on the year, while the Guardians have dropped to 40-41. Odds have been set for the series finale, and it's now time to make some predictions.

Cardinals vs. Guardians prediction

Logan Allen is pitching today - Source: Imagn

The St. Louis Cardinals are coming into this game with a ton of momentum on offense as they have had great success in this series, totaling 14 runs. This season, Willson Contreras is leading the way with 11 home runs and 51 runs driven in.

Matthew Liberatore is taking the mound against Cleveland, and he has pitched solidly this season. The lefthander has gone 5-6 with a 3.96 ERA so far in 2025 and he projects to have a decent start on Sunday.

Logan Allen is going to be on the mound for the Guardians. He has gone 5-5 with a 4.25 ERA this season, and he looks to improve against a Cardinals team that has won seven of its last 10.

Jose Ramirez is doing all he can for the Guardians at the plate with 13 home runs and 38 RBIs this season. In need of a win and some better form, expect the Guardians to play cleaner baseball and come away with the win on Sunday.

Cardinals vs. Guardians odds

Money Line: St. Louis Cardinals -120, Cleveland Guardians - EVEN

Run Spread: Cardinals -1.5 (+140), Guardians +1.5 (-165)

Total Runs: Over 8.5 (-105), Under 8.5 (-115)

Cardinals vs. Guardians injuries

St. Louis Cardinals injury report

Jordan Walker (OF): 10-Day IL (Appendicitis)
Ivan Herrera (C/DH): 10-Day IL (Left hamstring strain)
Zack Thompson (LHP): 60-Day IL (Left lat strain)

Cleveland Guardians injury report

Shane Bieber (RHP): 60-Day IL (Right UCL Tear)
John Means (LHP): 60-Day IL (Left elbow surgery)
Paul Sewald (RHP): 15-Day IL (Right posterior deltoid strain)

Cardinals vs. Guardians picks

This series has been dominated by the Cardinals up to this point, but expect the Guardians to get the job done and record a 5-2 win.

Money Line: Cleveland Guardians (EVEN)

Run Spread: Guardians +1.5 (-165)

Total Runs: Under 8.5 (-115)

About the author

Ryan Burks is a baseball journalist at Sportskeeda with over 7 years of experience in the field, writing for publications such as Knup Sports. Ryan graduated from Elmhurst College in 2009 with a degree in Communications.

Ryan is a huge Chicago Cubs fan and enjoys their storied history and traditions. His favorite sporting moment was when the Cubs won the 2016 World Series, breaking a championship drought that dated back to 1908.

His favorite player was Ken Griffey Jr., as Ryan grew up during his prime and he was the coolest player in league history. Greg Maddux also deserves a mention, as he was truly amazing on the mound.

When not working or watching sports, Ryan coaches basketball and baseball, loves fishing, and spends time with his family.

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Edited by John Maxwell

Cardinals vs. Guardians: Game 3 prediction, odds, injuries, and picks - June 29, 2025