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#4 Defeat against Bolivia in a World Cup qualification game (2009)
The South American minnows thrashed La Albiceleste 6-1 in a World Cup qualification game as Argentina suffered their worst defeat in 60 years. Diego Maradona's team struggled to cope with the high altitude and succumbed to a huge defeat.
The two-time world champions were completely outplayed by the Bolivia side as 21-year-old Lionel Messi failed to influence the game. Striker Joaquin Botero scored a hat-trick for the home team while Luis Gonzalez scored the solitary goal for the visitors.
The impact of the result in the overall context was minimal as Argentina qualified for the 2010 World Cup with ease. But, the defeat still remains one of the worst of Lionel Messi's footballing career.
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