Milli komanda have already been eliminated from the race for next year's showpiece with four defeats in five games.
Having accumulated just a single point so far, they're at the bottom of Group A and hovering just above them is Stephen Kenny's Boys in Green.
It's been an underwhelming campaign for them as they have struggled with disappointing results, including a stunning 1-0 home loss to minnows Luxembourg.
Trailing leaders Portugal by a massive 11 points with only three games remaining, their hopes of securing a direct qualification are over.
But Ireland can still come second and progress into the playoff round, provided they win all their fixtures and Serbia fumble in their matches.
Azerbaijan vs Ireland Head-To-Head
The 1-1 draw in September was their very first clash in history.
Now, the sides meet for only the second time.
Azerbaijan Form Guide (all competitions): L-D-L-L-W
Ireland Form Guide (all competitions): D-D-L-D-W
Azerbaijan vs Ireland Team News
Gianni De Biasi faces a dilemma in defense over whether to revert to a back-four or retain the five-man defense he played against Portugal.
The midfield, however, is sorted, with Gara Garayev, Toral Bayramov and Emin Mahmudov all expected to start in the middle.
Ramil Sheydayev, who's two shy of becoming Azerbaijan's joint second-highest scorer, is hoping to come into the XI.
He's started on the bench in all five of their qualifying games so far but faces competition from Ali Ghorbani and Mahir Emreli.
Everton star Michael Keane's younger brother Will Keane has received his maiden call-up and will be raring to earn his first international cap.
His selection only intensifies competition for places in the attacking vanguard as Stephen Kenney is now left to choose from eight forwards!
Defensive duo skipper Seamus Coleman and Dara O'Shea have been ruled out for this month's fixtures with injuries. Ryan Manning also withdrew due to an ankle injury and will be replaced by Liam Scales.
Alan Browne and Jason Molumby are unavailable due to suspension.
Injured: Seamus Colema, Dara O'Shea, Ryan Manning
Suspended: Alan Browne, Jason Molumby
Azerbaijan vs Ireland Predicted XI
Azerbaijan (4-3-3): Shahrudin Mahammadaliyev; Maksim Medvedev, Elvin Badalov, Hojjat Haghverdi, Anton Krivotsyuk; Emin Mahmudov, Gara Garayev, Toral Bayramov; Namik Alasgkarov, Ali Ghorbani, Filip Ozobic.
Ireland (3-4-1-2): Gavin Bazunu; Cyrus Christie, Shane Duffy, John Egan; Matt Doherty, Conor Hourihane, Jeff Hendrick, James McClean; Callum Robinson; Troy Parrott, Adam Idah.
Azerbaijan vs Ireland Prediction
Ireland were given a hard time by Azerbaijan in their first encounter, snatching only a draw with a late, late strike.
Milli komanda are tough to beat at home too and Stephen Kenny's side can expect a serious challenge from them once more.
As much as revenge is on their minds, another stalemate seems like the most probable outcome.
Prediction: Azerbaijan 1-1 Ireland