Barcelona SC lock horns with Fluminense in Copa Libertadores quarter-final action on Thursday at Estadio Monumental Banco Pichincha. The first leg fixture in Brazil last week ended in a 2-2 draw, with Fluminense equalizing in the fifth minute of injury time.The hosts suffered their first defeat of the 2021-22 campaign at Oresne while Fluminense's 4-2 loss against Internacional was their fourth defeat in a row in the Brazilian Serie A.Fluminense are one of five Brazilian sides left in the tournament and if they progress, chances are they might very well end up facing familiar opponents in the semi-finals.🏆 ¡Hoy comienzan a definirse los cuartos de final de la CONMEBOL #Libertadores! 😱🔜 Esta semana se conocerán los 4⃣ equipos que seguirán rumbo a la #GloriaEterna. ¿Quiénes pasarán a las semifinales? pic.twitter.com/wu98Aimgy0— CONMEBOL Libertadores (@Libertadores) August 17, 2021Barcelona SC vs Fluminense Head-to-HeadThe first leg meeting at the Maracana last week was the first-ever encounter between the two sides. The game turned out to be an exhilarating affair, with Fluminense taking the lead in the 26th minute.Barcelona thought they had completed a comeback with a goal in the 69th minute and Gabriel Cortez's penalty in the 88th minute, but Fred scored in injury time to salvage a point for Fluzão.Barcelona SC form guide (all competitions): L-D-W-W-WFluminense form guide (all competitions): L-D-L-W-WBarcelona SC vs Fluminense Team NewsBarcelona SCPedro Pablo Velasco, Darío Aimar and Michael Hoyos remain ruled out on account of injuries. Leandro Emmanuel Martínez was awarded a red card in the first leg and is suspended for the game.Injured: Pedro Pablo Velasco, Darío Aimar, Michael HoyosDoubtful: NoneSuspended: Leandro Emmanuel MartínezFluminense Caio Paulista has been receiving treatment for a thigh injury and is expected to be included in the squad that travels to Ecuador. He faces a late fitness test before the game.Hudson is another injury concern while Gabriel Teixeira won't be making the trip after getting married earlier in the week.Depois da manhã de treinos no CT Carlos Castilho, o #TimeDeGuerreiros viaja para Guayaquil na tarde desta terça. Quinta-feira tem decisão! 📸: Mailson Santana/FFC pic.twitter.com/U9fT2M18xB— Fluminense F.C. (@FluminenseFC) August 17, 2021Injured: Hudson, Caio PaulistaSuspended: NoneUnavailable: Gabriel TeixeiraBarcelona SC vs Fluminense Predicted XIBarcelona Predicted XI (4-2-3-1): Javier Burrai; Byron Castillo, Fernando Leon, Williams Riveros, Mario Pineida; Nixon Molina, Bruno Pinatares; Jonathan Perlaza, Damian Diaz, Carlos Garcés; Gonzalo MastrianiFluminense Predicted XI (4-3-3): Marcos Felipe; Samuel, Nino, Luccas Claro, Egidio; Matheus Martinelli, Yago, André; Luiz Henrique, Abel Hernández, FredBarcelona SC vs Fluminense PredictionFluminense had to wait until injury time to rescue a point in the first leg. They have scored goals in their recent outings but have conceded more. Barcelona suffered their first defeat of the campaign but are still undefeated at home.We predict the game will end in a narrow win for the Ecuadorian side, though a clean sheet does not look likely.Prediciton: Barcelona SC 2-1 FluminenseAlso See: Fabrizio Romano's Transfer Roundup: Neymar's role in Lionel Messi's transfer to PSG, Chelsea's transfer plans and more