Bayer Leverkusen vs PSV Eindhoven Prediction and Betting Tips | October 1st 2025

Bayer 04 Leverkusen v Eintracht Frankfurt - Bundesliga - Source: Getty
Bayer Leverkusen and PSV Eindhoven square off in the UEFA Champions League on Wednesday

Bayer Leverkusen and PSV Eindhoven will both be out to secure their first UEFA Champions League win of the campaign when they square off at BayArena on Wednesday. The Eredivisie outfit are on a run of eight straight competitive away victories since March and will look to extend this hot streak.

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Bayer Leverkusen picked up a morale-boosting result ahead of Wednesday’s return to the Champions League when they secured a 2-1 victory over St. Pauli in their Bundesliga clash on Saturday.

Since kicking off the league campaign with a disappointing 2-1 home defeat against Hoffenheim in August, Kasper Hjulmand’s men have now gone six consecutive matches without defeat, claiming three wins and three draws in that time.

Leverkusen now turn their focus to the Champions League, where they aim to pick up their first win of the campaign after fighting back from behind twice to salvage a 2-2 draw against Copenhagen in their group opener on September 18.

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As for PSV Eindhoven, they were left red-faced in their Champions League curtain-raiser on September 16, when they fell to a 3-1 defeat against Belgian outfit Union Saint-Gilloise on home turf.

This was followed by a 2-2 stalemate with Ajax on September 21, when they conceded an 88th-minute equaliser at the Philips Stadion, before bouncing back in a 2-1 victory over Excelsior at the Stadion Woudestein on Saturday.

PSV will be backing themselves to get up and running in the Champions League on Wednesday as they journey to the BayArena on a run of eight straight competitive away victories, stretching back to March 12, when they played out a 2-2 draw with Arsenal in the UCL round of 16.

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Bayer Leverkusen vs PSV Eindhoven Head-To-Head and Key Numbers

  • This will be the first-ever meeting between Bayer Leverkusen and PSV Eindhoven, and both sides will be out to begin their head-to-head record on a positive note.
  • Bayern Leverkusen have failed to win four of their last five Champions League matches, losing three and picking up one draw while conceding nine goals and scoring five since the turn of the year.
  • Like the home side, PSV Eindhoven have managed just one win in their most recent five UCL games while claiming one draw and losing three, including a 7-1 hammering against Arsenal in March.
  • Leverkusen have picked up just three wins from their last 10 home matches across all competitions while losing four and claiming three draws since mid February.
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Bayer Leverkusen vs PSV Eindhoven Prediction

Following their shock opening-day loss against Saint-Gilloise, PSV Eindhoven will be looking to bounce back at the BayArena and get their European quest up and running.

However, Leverkusen have upped the ante since their slow start to the season and we predict they will make the most of their home advantage to secure all three points, albeit by the odd goal.

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Prediction: Bayer Leverkusen 2-1 PSV Eindhoven


Bayer Leverkusen vs PSV Eindhoven Betting Tips

Tip 1: Result - Leverkusen to win

Tip 2: Both sides to score - Yes (Both teams have scored in Leverkusen’s last seven matches)

Tip 3: Over 2.5 goals - Yes (There have also been three or more goals scored in seven of the hosts’ last eight matches)

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Edited by Ashwin Hanagudu
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