Club America go head-to-head with Santos Laguna at Estadio Azteca in their upcoming Liga MX Apertura clash on Wednesday.The hosts extended their lead at the top of the standings as they recorded a narrow win over Atletico San Luis on Saturday. Roger Martínez scored the winning goal in the seventh minute of injury time. Second-placed Atlas lost 1-0 to Mazatlan, giving a six-point cushion to Club America at the top of the table.Santos Laguna played a 1-1 draw in their trip to Pachuca, with Fernando Gorriarán scoring the equalizing goal in the 89th minute from the penalty spot.Liga BBVA MX@LigaBBVAMX#JugadorDelPartido: @gibranlajud25 mostró sus cualidades en el arco, el portero de @ClubSantos nos regaló grandes atajadas ante los Tuzos en la 'Bella Airosa' Estas fueron sus cifras @CITEC_Futbol#LigaBBVAMX ⚽ #TuVidaNoEsUnJuego8:11 AM · Oct 17, 20211019#JugadorDelPartido: @gibranlajud25 mostró sus cualidades en el arco, el portero de @ClubSantos nos regaló grandes atajadas ante los Tuzos en la 'Bella Airosa' Estas fueron sus cifras @CITEC_Futbol#LigaBBVAMX ⚽ #TuVidaNoEsUnJuego https://t.co/5Y7odbAtF6Club America vs Santos Laguna Head-to-HeadThere have been 55 meetings between the two teams across all competitions since 2000. As expected, the hosts have been the dominant side in these encounters and have 28 wins to their name.Santos Laguna have been victorious 14 times over the capital club and the spoils have been shared 13 times in this fixture. They have been evenly matched in their last 11 meetings, with four wins for each side and three games ending in stalemates.They last squared off at Estadio Corona in Clausura 2021. The game ended in a 1-1 draw, with Santiago Muñoz canceling out Henry Martin's first-half goal in the 81st minute.Club America form guide (Liga MX): W-W-D-D-LSantos Laguna form guide (all competitions): D-W-L-D-LClub America vs Santos Laguna Team NewsClub AmericaJorge Sánchez and Emanuel Aguilera picked up injuries during the international break and missed the trip against San Luis. The game comes a bit too soon for the duo.Renato Ibarra and Leonardo Suarez are long-term absentees, while Santiago Naveda is a doubt as he was not present in the squad against San Luis despite returning to training last week.Club América@ClubAmerica🎥 | De vuelta al Nido 🦅 y empezamos a preparar la Jornada 1️⃣4️⃣.#SiempreÁguilas 🔵🟡10:07 AM · Oct 17, 202144226🎥 | De vuelta al Nido 🦅 y empezamos a preparar la Jornada 1️⃣4️⃣.#SiempreÁguilas 🔵🟡 https://t.co/32GqyOUFT4Injured: Renato Ibarra, Leonardo Suarez, Jorge Sánchez, Emanuel AguileraDoubtful: Santiago NavedaSuspended: NoneSantos LagunaClub captain and goalkeeper Carlos Acevedo Lopez is the only injury concern for the visiting side here. He suffered a shoulder injury in August and is expected to be back in the fold by December.Ignacio Jeraldino was substituted off with an injury in the 1-1 draw against Pachuca and is a doubt for this trip to Mexico City.Injured: Carlos Acevedo LopezDoubtful: Ignacio JeraldinoSuspended: NoneClub America vs Santos Laguna Predicted XIClub America Predicted XI (4-2-3-1): Guillermo Ochoa; Luis Fuentes, Sebastian Caceres, Bruno Valdez, Salvador Reyes Chávez; Pedro Aquino, Richard Sánchez; Sebastián Córdova, Nicolás Benedetti, Alvaro Fidalgo; Roger MartinezSantos Laguna Predicted XI (4-3-3): Manuel Lajud; David Alfredo Andrade, Dória Macedo, Omar Campos, Emilio Orrantia; Fernando Gorriarán, Jordan Carrillo, Juan Ferney Otero; Diego Valdes, Eduardo Aguirre, Jesús OcejoClub America vs Santos Laguna PredictionClub America are unbeaten in their last four games and have recorded back-to-back wins. Santos Laguna have had just one win in their last five outings and could struggle in this away game.Club America have earned three clean sheets in their last four outings, so we expect them to secure a narrow win and a clean sheet.Prediction: Club America 1-0 Santos Laguna