Club Brugge will host Bayer Leverkusen at the Jan Breydel Stadium on Wednesday night in the opening week of the 2022-23 UEFA Champions League campaign.The Belgian club have enjoyed a solid start to their season. They picked up a clinical 4-0 win over Cercle Brugge in the Bruges Derby on Friday and will now turn their attention to Europe. Brugge have made the UEFA Champions League group stage in the last four seasosn but have failed to advance to the knockouts each time.Leverkusen, meanwhile, have struggled this season, sitting in the bottom half of the Bundesliga standings. They were beaten 3-2 by Freiburg in their last game and will hope for better luck in the continent. View this post on Instagram Instagram PostDie Werkself opened their European campaign last season with a 2-1 comeback win over Ferencvarosi and will look to start on a positive note once again.Club Brugge vs Bayer Leverkusen Head-to-HeadWednesday's game will mark just the second meeting between Brugge and Leverkusen. Their first meeting came in the UEFA Europa League group stage in the 2006-07 campaign, which ended 1-1.Club Brugge Form Guide (all competitions): W-W-W-W-DBayer Leverkusen Form Guide (all competitions): L-W-L-L-LClub Brugge vs Bayer Leverkusen Team NewsClub BruggeClinton Mata came off injured in the derby last week and is a major doubt for this one. Noa Lang, Tajon Buchanan and Mats Rits have all been ruled out with injury.Injured: Noa Lang, Tajon Buchanan, Mats RitsDoubtful: Clinton MataSuspended: NoneUnavailable: NoneBayer LeverkusenThe visitors also have a few absentees ahead of their European opener. Amine Adli, Florian Wirtz, Karim Bellarabi and goalkeeper Andrey Lunev will miss out due to injury.Injured: Amine Adli, Florian Wirtz, Karim Bellarabi, Andrey LunevDoubtful: NoneSuspended: NoneUnavailable: NoneClub Brugge vs Bayer Leverkusen Predicted XIsClub Brugge (3-5-2): Simon Mignolet; Brandon Mechele, Raphael Onyedika, Abakar Sylla; Andreas Skov Olsen, Casper Nielsen, Hans Vanaken, Denis Odoi, Bjorn Meijer; Kamal Sowah, Ferran Jutgla View this post on Instagram Instagram PostBayer Leverkusen (3-5-2): Lukas Hradecky; Edmond Tapsoba, Jonathan Tah, Piero Hincapie; Jeremie Frimpong, Robert Andrich, Exequiel Palacios, Kerem Demirbay, Callum Hudson-Odoi; Moussa Diaby, Patrik SchickClub Brugge vs Bayer Leverkusen PredictionThe Blauw-Zwart are on a four-game winning streak and have lost just one of their eight games across competitions this season. They are unbeaten in their last ten competitive games at the Jan Breydel Stadium.The visitors have won just once this season across competitions. The Belgian outfit are in much better form ahead of their European opener and should come out on top.Prediction: Club Brugge 2-1 Bayer Leverkusen