In their previous game, Belgium beat Wales 3-1 at the King Power Stadium in Leuven. Harry Wilson gave Wales the lead in the 10th minute to boost Welsh hopes, but that was quickly shut down.
Kevin de Bruyne and Thorgan Hazard gave Belgium the lead before halftime. A Romelu Lukaku penalty in the second half secured the points for the Belgians.
The Czech Republic and Belgium are the favorites to finish in the top two of this group, which also consists of Belarus, Estonia and Wales.
The Czechs began their campaign with a comfortable win as they beat Estonia 6-2 in Talinn on Wednesday night.
Tomas Soucek continued his magnificent form this season, scoring a hat-trick in that game to get the Czech campaign off to the ideal start.
Czech Republic vs Belgium Head-to-Head
The head-to-head record between the two sides is deadlocked after seven games played. They have won three games each against the other, drawing the remaining fixture.
Czech Republic vs Belgium Team News
It is unlikely that the Czechs will make any changes ahead of this game. They have no concerns related to injuries or suspensions.
With Eden Hazard injuring his ankle earlier this month, he's the only player missing for Belgium ahead of the game. Jason Denayer is likely to come into the back three, with Thomas Vermaelen expected to be the player to make way.
Injured: Eden Hazard
Unavailable: Thomas Vermaelen, Yannick Carrasco
Czech Republic vs Belgium Predicted XIs
Czech Republic Predicted XI (4-2-3-1): Tomas Vaclik; Vladimir Coufal, Pavel Kaderabek, Ales Mateju; Ondrej Kudela; Tomas Soucek, Alex Kral; Lukas Masopust, Vladimir Darida, Jakub Jankto; Patrik Schick
Belgium Predicted XI (3-4-2-1): Thibaut Courtois; Toby Alderweireld, Jason Denayer, Jan Vertonghen; Thomas Meunier, Youri Tielemans, Leander Dendoncker, Alexis Saelemaekers; Kevin De Bruyne, Dries Mertens; Romelu Lukaku
Czech Republic vs Belgium Prediction
The Czechs come into this game with momentum on the back of a big win against Estonia. However, Belgium are also confident following their victory over Wales.
Belgium have the talent and in-form players to test the Czechs in this game and pose a serious threat in attack.
We are predicting that Belgium will win this game.
Prediction: Czech Republic 0-2 Belgium