Both teams have excellent players in their ranks and will be determined to win this classic European encounter.
Italy are at the top of their group at the moment and will need to work hard to remain ahead of the curve. The Azzurri played out a 0-0 stalemate against England over the weekend and will aim to take it up a notch in this fixture.
Germany, on the other hand, are in third place in their group and have plenty of work to do ahead of this match. Die Mannschaft were held to a 1-1 draw by Hungary in their previous game and will need to bounce back this week.
Germany vs Italy Head-to-Head
Italy have a slight edge over Germany and have won 15 of the 36 matches played between the two sides. Germany have managed 11 victories against Italy and will want to cut the deficit on Tuesday.
The previous meeting between the two European giants took place last week and ended in a 1-1 draw. Both teams squandered chances on the day and will need to be more clinical this week.
Germany form guide: D-D-D-D-W
Italy form guide: D-W-D-L-W
Germany vs Italy Team News
Marco Reus has sustained a muscle injury and has been ruled out of the remainder of his team's games this month. Serge Gnabry is also yet to hit full fitness and might not feature in this match.
Injured: Marco Reus
Doubtful: Serge Gnabry
Domenico Berardi, Ciro Immobile, Federico Chiesa and Gaetano Castrovilli are injured and have been ruled out of the fixture. Giorgio Chiellini played his last Italy match against Argentina last week and will not be included in the squad.
The Italians have clearly shifted their focus to a younger set of players, including the likes of Sandro Tonali, Gianluca Scamacca and Alessandro Bastoni. Tonali will be suspended for this match due to yellow card accumulation.
Alessandro Florenzi and Tommaso Pobega have been released from the national team camp for various personal reasons ahead of the Germany game.
Injured: Domenico Berardi, Ciro Immobile, Federico Chiesa, Gaetano Castrovilli, Rafael Toloi, Nicolo Zaniolo, Mattia Zaccagni, Andrea Pinamonti, Moise Kean
Suspended: Sandro Tonali
Unavailable: Giorgio Chiellini, Alessandro Florenzi, Tommaso Pobega
Germany vs Italy Predicted XI
Germany Predicted XI (4-2-3-1): Manuel Neuer; Lukas Klostermann, Antonio Rudiger, Niklas Sule, David Raum; Joshua Kimmich, Leon Goretzka; Jamal Musiala, Thomas Muller, Leroy Sane; Timo Werner
Italy Predicted XI (4-3-3): Gianluigi Donnarumma; Giovanni Di Lorenzo, Alessandro Bastoni, Francesco Acerbi, Davide Calabria; Matteo Pessina, Bryan Cristante, Nicolo Barella; Lorenzo Pellegrini, Matteo Politano, Gianluca Scamacca
Germany vs Italy Prediction
Germany are yet to hit their peak in the UEFA Nations League and have drawn all their games in the competition this season. Die Mannschaft have a host of young players at their disposal and have a point to prove this week.
Italy are in a transitional phase at the moment and will need to work hard to defeat their traditional rivals. Both teams have issues to address at the moment and could play out yet another draw on Tuesday.
Prediction: Germany 1-1 Italy