The home side come into the game on the back of a harrowing 1-0 defeat away to Saudi Arabia. Feras Al Brikan scored the winning goal in the 71st minute.
Australia secured a routine 3-1 victory over Oman in their 'home' game. The match was played at the Khalifa International Stadium in Doha, as Australia have not been able to play their matches at home due to strict COVID-19 travel restrictions.
Awer Mabil, Martin Boyle and Mitchell Duke all got on the scoresheet for the Socceroos in a comprehensive victory.
Japan's defeat left them in third place in Group B and put them in danger of missing out on automatic qualification for Qatar 2022.
The Blue Samurai have garnered just three points from three matches. Australia lead the way at the summit with maximum points garnered from three games.
Japan vs Australia Head-to-Head
This will be the 25th meeting between the two sides and Japan have the better record with 10 wins to their name. Australia were victorious on six occasions while eight matches in the past ended in a share of the spoils.
Their most recent meeting came in a 2018 FIFA World Cup qualifier when Takuma Asano and Yosuke Ideguchi scored in either half to give Japan a 2-0 home win.
Japan form guide: L-W-L-W-W
Australia form guide: W-W-W-W-W
Japan vs Australia Team News
Premier League duo Takehiro Tomiyasu and Takumi Minamino, as well as captain Maya Yoshida, headline the squad of 26 Japanese players to dispute October's qualifiers.
Mathew Ryan and Aaron Mooy were among the 25 Australian players called up for October's international window.
Japan vs Australia Predicted XI
Japan Predicted XI (4-2-3-1): Shuichi Gonda (GK); Yuyto Nagatomo, Maya Yoshida, Yuta Nakayama, Takehiro Tomiyasu; Wataru Endo, Gaku Shibasaki; Takuma Asano, Daichi Kamada, Takumi Minamino; Yuya Osako
Australia Predicted XI (4-3-3): Matthew Ryan (GK); Aziz Behich, Harry Souttar, Trent Sainsbury, Rhyan Grant; Aaron Mooy, Ajdin Hrustic, Tom Rogic; Awer Mabil, Mitchell Duke, Adam Taggart
Japan vs Australia Prediction
Japan's poor start to the qualifiers has left them playing catch-up and anything other than a win here could be detrimental to their chances of automatic qualification.
In light of this, the hosts will go all out for victory and this could leave them susceptible at the back. Both sides have enough quality to find the back of the net and we are predicting a share of the spoils in a thrilling draw.
Prediction: Japan 2-2 Australia