The sides occupy the bottom two places in Group C and have already been eliminated from the race for the third qualifying round.
Liberia are fourth with only three points from five games, losing all bar one - a 1-0 victory over the Central African side in September. They were also beaten 2-0 by group leaders Nigeria on Saturday courtesy of two penalties.
Now, the Lone Star be hoping to at least get off the bottom of the table and finish in third place. Central African Republic, meanwhile, are hovering just a point above them after losing 2-1 to Cape Verde Islands on Saturday, their second consecutive loss of the campaign.
Liberia vs Central African Republic Head-To-Head
Their reverse fixture in September was the first official clash between the sides.
Liberia won the game 1-0.
Liberia Form Guide (all competitions): W-L-L-L-L
Central African Republic (all competitions): D-L-W-L-L
Liberia vs Central African Republic Team News
Despite the loss, Liberia manager Peter Butler would still be content with his side's performance, as Nigeria needed two penalties to overcome them.
Slavia Praha midfielder Oscar Dorley is set to earn his 25th cap for the Lone Star.
Central African Republic
With their hopes of progression over, head coach Raoul Savoy might hand international debuts to Brad Pirioua and Severin Tatolna. However, experienced midfielder Junior Gourrier might also come into the XI, having only made a substitute appearance in the loss to Cape Verde on Saturday.
Liberia vs Central African Republic Predicted XI
Liberia (5-3-2): Tommy Songo; Mark Pabai, Jamal Arago, Prince Balde, Brem Soumaoro, Oscar Dorley; Seth Hellberg, Sampson Dweh, Marcus Macauley; Abu Kamara, Peter Wilson.
Central African Republic (4-4-2): Prince Samolah; Thibault Ban, Peter Guinari, Sadack Ndobé, Saint-Cyr Ngam Ngam; Jospin Gaopandia, Tresór Toropité, Junior Gourrier, Brad Pirioua; Karl Namnganda, Severin Tatolna.
Liberia vs Central African Republic Prediction
Both sides have been eliminated from the race for a place in the third round and only have pride at stake here. Given the lack of genuine quality in their ranks, we're predicting a low-scoring draw here.
Prediction: Liberia 1-1 Central African Republic