#1 Deep defensive line:
Liverpool has already scored 70 goals in the Premier League this season and only Manchester City have more goals than them. The front-line of Sadio Mane, Roberto Firmino and Mohammed Salah has scored 45 times this season. Stopping the trio is a hard task for any team and is Pochettino's biggest concern. Moreover, the devastating form of Sadio Mane could be the biggest headache for Spurs' defenders.
Tottenham Hotspur should keep a deep line of defense to stop Liverpool from attacking their goal. Toby Alderweireld is likely to start the match with fellow Belgian Jan Vertonghen. Not only the central defenders; but also the full backs should drop deep and have strict defensive responsibilities.
Liverpool has always proved themselves as a threatening counter-attacking side. If Spurs' defense could stop Liverpool's attack at Anfield, it will give them a good chance of taking all three points. The task is not easy for travelers, but Liverpool are under pressure and Pochettino's men could take advantage of it.