The home side come into the game on the back of a 2-1 defeat away to league leaders Bournemouth on Saturday. Philip Billing and Dominic Solanke scored first-half goals to guide the Cherries to all three points.
Coventry City secured a comfortable 3-0 victory over Peterborough on home turf. Gustavo Hamer's strike and Viktor Gyokeres' second-half brace saw the Sky Blues cruise to victory.
That victory helped the west Midlands outfit climb up to third place in the table, with 19 points garnered from nine matches. Luton Town are in 16th place and are just five points above the dropzone.
Luton Town vs Coventry City Head-to-Head
The two sides have clashed on 84 occasions in the past and Coventry City have a better record, with 41 wins to their name. The two sides shared the spoils on 17 occasions while Luton town were victorious in 26 games.
Their most recent meeting came in March when first-half goals from James Bree and Elijah Adebayo gave Luton Town a 2-0 victory on home turf.
The home side's defeat to Bournemouth halted a run of four consecutive draws and they will be keen to get back to winning ways. Coventry City have won three of their last five matches.
Luton Town form guide: L-D-D-D-D
Coventry City form guide: W-D-W-W-L
Luton Town vs Coventry City Team News
Admiral Muskwe (leg), Fred Onyedinma (ligament) and Allan Campbell (ligament) have all been sidelined by fitness issues. There are no suspension worries for the hosts.
Injuries: Admiral Muskwe, Fred Onyedinma, Allan Campbell
Josh Eccles has been ruled out with a hip injury. Fankaty Dabo will serve out the final match of his three-game suspension for the red card he picked up against Cardiff City.
Injury: Josh Eccles
Suspension: Fankaty Dabo
Luton Town vs Coventry City Predicted XI
Luton Town Predicted XI (4-3-3): Simon Sluga (GK); Kal Naismith, Reece Burke, Tom Lockyer, James Bree; Luke Berry, Glen Rea, Gabriel Osho; Jordan Clark, Elijah Adebayo, Harry Cornick
Coventry Predicted XI (3-4-3): Simon Moore (GK); Jake Clarke-Salter, Kyle McFadzean, Dominic Hyam; Ian Maatsen, Gustavo Hamer, Ben Sheaf, Todd Kane; Callum O'Hare, Viktor Gyokeres, Martyn Waghorn
Luton Town vs Coventry City Prediction
Coventry City have been the more consistent side this season, although Luton have home advantage in their favor. The Hatters have started the season brightly and will want to push on to maintain their playoff spot.
The hosts have struggled defensively, although their attack is the best in the bottom half and we are backing Mark Robins' side to triumph with goals at both ends.
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Prediction: Luton Town 1-2 Coventry City