A massive 13 points separate the two teams in the league table, with the Red Devils on course to finish ahead of their Northwest rivals for the first time in three years.
While Manchester United have recovered from a poor start to the campaign, Liverpool's season has gone completely off the boil since the turn of the year, so much so that even their Champions League hopes are now hanging in the balance.
The defending champions are sixth in the league table, four points off fourth-placed Chelsea, after drawing their last two games. Liverpool now face an uphill battle in a fixture they usually struggle with, especially at Old Trafford.
Meanwhile, Manchester United couldn't keep up with runaway leaders Manchester City but are on course for a strong finish to their campaign. They also have one foot in the 2021 Europa League final.
Ahead of this mouth-watering game, let's have a look at how Liverpool and Manchester United would stack up in a hypothetical combined XI:
Goalkeeper: Alisson (Liverpool)
It hasn't been his best season by any stretch of imagination, but Liverpool custodian Alisson gets into our hypothetical combined XI. That's because Manchester United have constantly swapped between Dean Henderson and David de Gea this season, and neither has been truly convincing between the sticks.
Alisson, meanwhile, has continued to be Liverpool's undisputed choice in goal. The 28-year old has managed only seven clean sheets this campaign but has produced moments of class in some tense moments, making jaw-dropping saves and helping Liverpool build from the back.