Since 2009, with Ronaldo's move from Manchester United to Real Madrid the game has set the stage for two of the greatest players in football, Lionel Messi and Cristiano Ronaldo, to go head-to-head in a masterclass showdown.
However, Ronaldo's surprise departure from the Bernabeu this summer has concluded the longstanding El Clasico rivalry between the two players. The Portuguese ace left Real Madrid to join Serie A side Juventus in a €117m deal.
Messi will also not be featuring in Sunday's El Clasico owing to an injury he picked up during Barcelona's 4-2 victory over Sevilla last Saturday.
After a goal and an assist, the Argentine ace fell and landed on his right arm, resulting in his injury. Barcelona has confirmed that Messi will face a recovery spell of at least three weeks.
Therefore, this will be the first El Clasico without Ronaldo or Messi in a decade.
As the decade-long rivalry has come to an end, we take a look at the stats to find out who was the more effective player in the duo's history with El Clasico:
#1 Most El Clasico wins
It appears the El Clasico showdown has been favorable to Lionel Messi over the years as the Argentine ace has won the game 17 times out of 38. This means the Barcelona captain has lost twelve times and drawn on nine occasions.
Cristiano Ronaldo, on the other hand, has tasted about half of Messi's success when it comes to El Clasico victories. The Portuguese has only won 8 out of 30 fixtures, losing 14 games and drawing on eight occasions.
Despite Messi having played in more El Clasico games than Ronaldo, his win percentage (44.7%) is still higher than that of Ronaldo's (26.7%).
El Clasico wins
Messi - 17 wins out of 38 games (44.7%)
Ronaldo - 8 wins out of 30 fixtures (26.7%)