The sides played out an entertaining 2-2 draw in the first leg at Historic Crew Stadium last week. Ake Arnaud Loba, Milton Valenzuela, Lucas Zalarayan and Jose Alvarado all got on the scoresheet to leave the tie firmly in the balance.
Monterrey followed their continental exertions with a 1-0 victory over Mazatlan FC in the Liga MX. Vincent Janssen scored the match-winning goal in the 16th minute to move the club up to fourth in the table.
Columbus Crew played out a goalless draw away to CF Montreal, their second consecutive goalless stalemate in the MLS this term.
Monterrey vs Columbus Crew Head-to-Head
Monterrey and Columbus Crew met for the first time last week and could not be separated in a 2-2 draw.
Monterrey are unbeaten in two consecutive matches in all competitions, having earlier lost three successive league games. Crew are unbeaten in five consecutive games, with the last three games ending in draws.
A place in the semifinal awaits the winner of this tie where they will face either Toronto FC or Cruz Azul.
Monterrey form guide: W-D-L-L-L
Columbus Crew form guide: D-D-D-W-W
Monterrey vs Columbus Crew Team News
Left-back Daniel Parra is the only known injury concern for Monterrey ahead Columbus Crew's visit. Parra is a long-term absentee with a ruptured knee ligament.
There are no suspension concerns for manager Javier Aguirre.
Injury: Daniel Parra
Four players have been sidelined for the visitors due to injuries. Perry Kitchen (thigh), Marlon Hairston (knee), Aidan Morris (ACL) and Kevin Molino (hamstring) are all unavailable for selection.
There are no suspension concerns for head coach Caleb Porter.
Injuries: Perry Kitchen, Marlon Hairston, Aidan Morris, Kevin Molino
Monterrey vs Columbus Crew Predicted XI
Monterrey Predicted XI (5-3-2): Luis Cardenas (GK); Jesus Gallardo, Sebastian Vegas, Adrian Mora, Axel Grijalva, Miguel Layun; Jonathan Gonzalez, Matias Kranevitter, Aviles Hurtado; Rogelio Funes, Ake Loba
Columbus Crew (4-4-1-1): Eloy Room (GK); Milton Valenzuela, Josh Williams, Darlington Nagbe, Harrison Afful; Pedro Santos, Aboubacar Keita, Artur, Diaz Espinoza; Lucas Zelarayan; Gyasi Zardes
Monterrey vs Columbus Crew Prediction
The two sides are virtually evenly matched and have what it takes to win and ensure progress to the semi-finals.
However, Monterrey have a long pedigree and home form could weigh heavily in their favor. We are predicting a share of the spoils in a low-scoring draw with the hosts qualifying on away goals.
Prediction: Monterrey 1-1 Columbus Crew