Varane has been named the captain of the side in the absence of goalkeeper Hugo Lloris. Didier Deschamps has also decided to hand international debuts to AS Monaco duo Benoit Badiashile and Youssouf Fofana.
Varane has been rock-solid at the back for United so far this season. The Frenchman has formed a solid partnership with new signing Lisandro Martinez for Erik ten Hag's side.
However, Manchester United fans are concerned that fielding the former Real Madrid star for the full 90 minutes could result in him getting injured. Given the importance of the centre-back to the Red Devils this season, any kind of fitness issue for the player would be a massive blow for the team.
Fans have gathered on social media hoping that the Frenchman doesn't pick up an untimely injury in the game. Here are some of the best reactions across Twitter:
Manchester United legend picks French superstar Kylian Mbappe in the latest brewing debate
Cristiano Ronaldo vs. Lionel Messi has been an eternal football debate for a while. However, a new debate between Kylian Mbappe and Erling Haaland is currently brewing.
Manchester United legend Paul Scholes recently gave his verdict on the debate. While speaking to his former teammate Gary Neville on The Overlap show, the iconic midfielder chose the Frenchman over the Norwegian.
While Scholes acknowledged that Haaland is amazing on his own merit, he believes Mbappe has more to offer in the game than just scoring goals. He said:
“I'd go Mbappe, there's more to his game. He's more than an out and out centre forward, he can go wide, he can dribble past people, he can play one twos.
"Look Haaland is f***ing amazing don't get me wrong but he's [just] a goalscorer isn't he.”
Watch Paul Scholes talk to Gary Neville:
Mbappe has scored 10 goals in nine games for Paris Saint-Germain this season. Haaland, 22, has had an absolutely astonishing start to his career at Manchester City after completing a £51 million summer move from Borussia Dortmund. He has scored 14 goals and provided an assist in 10 games for the Citizens so far this season.