Cristiano Ronaldo was left visibly frustrated during Manchester United's 3-1 win over Brentford in the Premier League on Wednesday after the Portuguese superstar was subbed off with 20 minutes to go. Ralf Rangnick's men remain seventh in the league table, but are now just two points off West Ham in 4th.Ronaldo returned to the starting XI to lead the line for the Red Devils on the night. Apart from that, Rangnick stuck to the same line-up that drew 2-2 against Aston Villa last time out.Brentford started off the game strongly, with Mattias Jensen, Christian Norgaard and Vitaly Janelt all coming close to scoring for Thomas Frank's side. Norgaard in particular spurned a great opportunity to open the scoring in the 15th minute. Jensen and Janelt also came close to scoring towards the end of the half but both teams went into half-time deadlocked at 0-0.Manchester United came out much the stronger side in the second-half as Cristiano Ronaldo saw his header loop onto the crossbar. The Portuguese superstar had been rather quiet up to this point in the game as the Brentford defenders did a good job of marking the forward.The Red Devils' pressure finally paid off in the 55th minute as Anthony Elanga latched onto Fred's through ball to score his first goal of the season. Following the goal, Rangick's side upped their tempo as they looked to finish off the game.Mason Greenwood soon doubled their lead as he finished off a clinical counter-attack after being set up by Bruno Fernandes. The game was over as a contest at this point as Brentford looked crestfallen after two quick-fire goals. Their misery was then compounded as Fernandes played through Marcus Rashford to make it 3-0 in the 77th minute and wrap up the game for the Red Devils.Brentford did have time to grab a consolation goal in the 85th minute, courtesy of Ivan Toney. However, Manchester United picked up all three points in what was a crucial game for Ralf Rangnick's men.Cristiano Ronaldo not happy with being subbed off by Manchester United boss RangnickCristiano Ronaldo was brought off for Harry Maguire in the 71st minute of the game, following the two quick goals by Manchester United. However, the forward looked shocked when he saw the board show his number. Ronaldo was visibly angry and threw his jacket on the floor before taking a seat in the dugout.Ronaldo's tally in the Premier League remains at eight goals in 17 appearances for United. With that being said, here are the best reactions from Manchester United's win against Brentford:ESPN FC@ESPNFCRonaldo was visibly upset after being subbed off (via @Slasherrrr) 3:51 AM · Jan 20, 20221046112Ronaldo was visibly upset after being subbed off 😤(via @Slasherrrr) https://t.co/kcuMz6C6DiManchester United@ManUtdA proud night for our #MUAcademy Anthony Elanga @MasonGreenwood @MarcusRashford #MUFC | #BREMUN3:32 AM · Jan 20, 2022148731799A proud night for our #MUAcademy 🙌🔴 Anthony Elanga ⚽️🔴 @MasonGreenwood ⚽️🔴 @MarcusRashford ⚽️#MUFC | #BREMUN https://t.co/7WQaQIkBvhMr Kassim👑@SmKTweetz17Ronaldos movement draws the CB out of position for Elanga to get in and scoreRonaldos chest opens Bruno to set up Greenwood for our 2ndBut Ronaldo is the problem 🥱2:53 AM · Jan 20, 202243359Ronaldos movement draws the CB out of position for Elanga to get in and scoreRonaldos chest opens Bruno to set up Greenwood for our 2ndBut Ronaldo is the problem 🥱Premier League@premierleague @MarcusRashford became the third different player to score 10 #PL goals as a substitute for Man Utd, after Ole Gunnar Solskjaer (17) and Javier Hernandez (14) #BREMUN4:45 AM · Jan 20, 20229019⚽ @MarcusRashford became the third different player to score 10 #PL goals as a substitute for Man Utd, after Ole Gunnar Solskjaer (17) and Javier Hernandez (14) ⚽#BREMUN https://t.co/SW5cranuVSRiZzy@RiZzyUTDHonestly man I’m so happy for Rashford, he looked broken the last few weeks. people don't understand how important confidence is in football3:22 AM · Jan 20, 20224335326Honestly man I’m so happy for Rashford, he looked broken the last few weeks. people don't understand how important confidence is in footballUtdFaithfuls@UtdFaithfuls2 goals and 2 assists in 2 games for Bruno Fernandes.Yes, he's BACK. Be scared, @premierleague.3:24 AM · Jan 20, 202213021452 goals and 2 assists in 2 games for Bruno Fernandes.Yes, he's BACK. Be scared, @premierleague. https://t.co/Tr4hEjjJptStatman Dave@StatmanDaveBruno Fernandes has been directly involved in 57 #PremierLeague goals at Man Utd: 71 appearances 33 goals 24 assists What a signing he’s been! 3:03 AM · Jan 20, 20221333154Bruno Fernandes has been directly involved in 57 #PremierLeague goals at Man Utd: 👕 71 appearances ⚽️ 33 goals 🅰️ 24 assists What a signing he’s been! 🙌 https://t.co/1BGVmbWrKkManchester United@ManUtd @Fred08Oficial Aston Villa (H) Aston Villa (A) Brentford (H) assists in games for our no.17 🤩#MUFC4:03 AM · Jan 20, 20224736461🇧🇷 @Fred08Oficial 👏🅰️ Aston Villa (H)🅰️ Aston Villa (A) 🅰️ Brentford (H)3️⃣ assists in 3️⃣ games for our no.17 🤩#MUFC https://t.co/bb2UqfnKqPGary Neville@GNev2Brentford 0-3 Manchester United (Youth)3:08 AM · Jan 20, 20226480351Brentford 0-3 Manchester United (Youth)ًEllis.@EIIisV3If you’re a Manchester United fan and have an agenda against David De Gea then your hard drive needs to be checked.2:03 AM · Jan 20, 20223337278If you’re a Manchester United fan and have an agenda against David De Gea then your hard drive needs to be checked.Ryaner@Ryaner1985Ronaldo to Rangnick as he's substituted... twitter.com/NoContextHearn…No Context Hearn@NoContextHearn3:09 AM · Jan 20, 2022818https://t.co/SrTOGLKyFmRonaldo to Rangnick as he's substituted... twitter.com/NoContextHearn…𝕾𝖚𝖘𝖍𝖓𝖆𝖙𝖆🔰@sush_mufcDonny van de Beek trying to look like Ralf Rangnick to try and make the starting XI 1:09 AM · Jan 20, 202225623Donny van de Beek trying to look like Ralf Rangnick to try and make the starting XI 😭 https://t.co/HoTzAikU3MCristiano Ronaldo Brasil@CR7BrasilRalf Rangnick................3:03 AM · Jan 20, 20221482115Ralf Rangnick................ https://t.co/168YM0vQLUCaden 🔴@lfc_cadenChristianity didnt work for Rangnick so he's converted to Judiasm10:07 AM · Jan 15, 20222312464Christianity didnt work for Rangnick so he's converted to Judiasm https://t.co/BeszJuOfwfNora@Just_a_tweetxRalf: ‘This is Harry Maguire farewell game, so I had to give him 15 mins. Hope u understand’ #BREMUN https://t.co/D1dUVh6KNn #BREMUN3:14 AM · Jan 20, 202242181Ralf: ‘This is Harry Maguire farewell game, so I had to give him 15 mins. Hope u understand’ 😂 #BREMUN https://t.co/D1dUVh6KNn #BREMUNESPN FC@ESPNFCNo player has more goal contributions for Man United since the start of December than Fred 2:49 AM · Jan 20, 20223346254No player has more goal contributions for Man United since the start of December than Fred 💫 https://t.co/tlXRgfzf9b