Manchester United and Cristiano Ronaldo crashed out of the Champions League after their 1-0 defeat to Atletico Madrid at Old Trafford on Tuesday. The Red Devils, who secured a 1-1 draw during the first leg of the Round of 16 clash in Madrid last month, were dumped after a goal from Renan Lodi in the 41st minute of the second leg.It was Ralf Rangnick's side that started the game on the front foot. Manchester United were buoyed by their 3-2 win over Tottenham Hotspur last Sunday as they showed during the opening exchanges of the game.The Red Devils came close to scoring through Anthony Elanga, who was on the receiving end of a cross from Bruno Fernandes. Despite directing his shot on goal, the 19-year-old winger could not beat Jan Oblak from close-range. The Atletico shot-stopper denied the attempt with his face.Soon, the visitors also registered their first attempt on target. Rodrigo De Paul launched a thunderous attempt on goal from distance, but David de Gea was equal to the task and pushed it away for a corner.Diego Simeone's men also had a goal disallowed after Marcos Llorente was ruled offside in the build-up to Joao Felix finding the back of the net. Although they were disappointed with the decision, replays suggested the linesman made the right call.Manchester United then conceded the only goal of the game when Lodi fired in a downward header at the far post after a cross from Antoine Griezmann in the 41st minute. The hosts complained about a foul in the build-up to the goal, but the referee disagreed and Atletico were awarded their lead.Cristiano Ronaldo cut a frustrated figure as Atletico Madrid restricted Manchester UnitedThe second half proved to be a vintage Atletico Madrid display. Cristiano Ronaldo and Manchester United were restricted to good effect as their frustration became palpable at Old Trafford.Considering his stellar record against Atletico Madrid in the past, the Red Devils would have been counting on Cristiano Ronaldo to bail them out yet again. However, the 37-year-old failed to do so as the second half progressed.Manchester United@ManUtd⏱ An hour has passed… We’re still searching for that leveller #MUFC | #UCL2:49 AM · Mar 16, 20222226200⏱ An hour has passed… We’re still searching for that leveller 🔎#MUFC | #UCL https://t.co/EeAi05ga5lOblak produced a stunning save from Raphael Varane towards the latter stages of the game, but Atletico Madrid stuck together as a unit and recorded a famous win.In the wake of Manchester United crashing out of the competition, Twitter was buzzing with reactions from all over the globe. Here are some of the best tweets:IAmPete™🐐@PIniomorDe Gea: I will keep a clean sheet today Maguire:#MUNATM2:50 AM · Mar 16, 20221De Gea: I will keep a clean sheet today 👊Maguire:#MUNATM https://t.co/TOI0J6MARaJosh Kench@JoshKench1I think Harry Maguire was born out of position #MUNATM2:50 AM · Mar 16, 202221I think Harry Maguire was born out of position #MUNATMDigbyOut_@DigbyOutName a worst footballer than Harry Maguire. I’ll wait … 2:50 AM · Mar 16, 202261Name a worst footballer than Harry Maguire. I’ll wait … 💅 https://t.co/dKyOkWN8euR.@FCBRan_Ronaldo trying to beat his man in big 20222:50 AM · Mar 16, 20221Ronaldo trying to beat his man in big 2022 https://t.co/xlSkCsD1W2Christopher@wardellzzzManchester United got the GOAT, yet they dont feed him the ball. Unbelievable! #ManUtd2:41 AM · Mar 16, 2022Manchester United got the GOAT, yet they dont feed him the ball. Unbelievable! #ManUtdAfc Max@afcmax22Ronaldo ghosting2:39 AM · Mar 16, 202213Ronaldo ghosting https://t.co/yubppL8DpzTrey@UTDTreyCorruption knocked us out of the Fa Cup.Corruption could knock us out of the Champions League now.Manchester United against the world2:19 AM · Mar 16, 20225135599Corruption knocked us out of the Fa Cup.Corruption could knock us out of the Champions League now.Manchester United against the worldR8 🚜🌾@NabyllionaireWatching United try to find Ronaldo in the box makes me appreciate Trent and Robbo so much more2:38 AM · Mar 16, 2022937Watching United try to find Ronaldo in the box makes me appreciate Trent and Robbo so much moreskipper@aiw1nMan Utd fans everytime Maguire's on the ball#mufc #mufcatm @12thmantweets_2:06 AM · Mar 16, 20225Man Utd fans everytime Maguire's on the ball#mufc #mufcatm @12thmantweets_ https://t.co/AkQgIhSMSESmartie@SecretSmartieRonaldo using his GOAT aura to win the game2:27 AM · Mar 16, 2022837Ronaldo using his GOAT aura to win the game https://t.co/U79sgjohpSTrey@UTDTreyLooking for a goal and we bring on Rashford 2:55 AM · Mar 16, 202273936Looking for a goal and we bring on Rashford 😭Suliman@s5566_Ronaldo trying to play off the wing at 372:51 AM · Mar 16, 20223Ronaldo trying to play off the wing at 37 https://t.co/hnNR9ou7uFSquint Eastwood@SquintFeastwoodMaguire stopped Ronaldo from scoring lmao i love him. Box office2:59 AM · Mar 16, 2022Maguire stopped Ronaldo from scoring lmao i love him. Box office🇮🇪@MCFC_TrooperIs ronaldo still showering? Why is he not on the pitch?2:59 AM · Mar 16, 20221Is ronaldo still showering? Why is he not on the pitch?CTID💎@misfermo2Why's no one talking about this Ronaldo disaster class2:59 AM · Mar 16, 20222Why's no one talking about this Ronaldo disaster classRoland@InMyMentalFree kick for Ronaldo to hit the wall for 300th million time3:01 AM · Mar 16, 2022Free kick for Ronaldo to hit the wall for 300th million timeTroll Football@TrollFootballAtleti players: "How are we supposed to beat Ronaldo? He has always knocked us out of the UCL."Simeone: “That is where Man Utd comes in.”3:23 AM · Mar 16, 20223745683Atleti players: "How are we supposed to beat Ronaldo? He has always knocked us out of the UCL."Simeone: “That is where Man Utd comes in.” https://t.co/b7p7dLSKcUThe xG Philosophy@xGPhilosophyCristiano Ronaldo accumulated 0.00(xG) against Atletico Madrid this evening.3:29 AM · Mar 16, 20221738283Cristiano Ronaldo accumulated 0.00(xG) against Atletico Madrid this evening.TC@totalcristianoCristiano Ronaldo going trophyless for the first time since 2009/10.3:29 AM · Mar 16, 20221459154Cristiano Ronaldo going trophyless for the first time since 2009/10.TC@totalcristianoThe first time Ronaldo didn’t register a G/A in a UCL tie he’s been eliminated in since 2011. Sigh.3:27 AM · Mar 16, 20221437137The first time Ronaldo didn’t register a G/A in a UCL tie he’s been eliminated in since 2011. Sigh.FootballFunnys@FootballFunnnysHow can you not start Ronaldo in your biggest game of the season? Man United missed him today.3:28 AM · Mar 16, 202214639How can you not start Ronaldo in your biggest game of the season? Man United missed him today. https://t.co/M9JelhZkMtDon@OpresiiAt least Messi got knocked out by Laliga leaders in an away game… Ronaldo ghosted and got knocked out at home to 4th placed Atletico Madrid.3:29 AM · Mar 16, 202222541At least Messi got knocked out by Laliga leaders in an away game… Ronaldo ghosted and got knocked out at home to 4th placed Atletico Madrid.😭😭Chris. 🏆🌍@EmenaIoCristiano Ronaldo trying to get out of United this summer3:29 AM · Mar 16, 2022492Cristiano Ronaldo trying to get out of United this summer https://t.co/bb53tmncFIGary Lineker 💙💛@GaryLinekerIt’s ‘this is Man Utd o’clock’.3:33 AM · Mar 16, 202230723It’s ‘this is Man Utd o’clock’.Aliyu Baba-Ari@Abba_ariPogba Rashford Bruno and Ronaldo today #MUNATL #UCL3:34 AM · Mar 16, 20222Pogba Rashford Bruno and Ronaldo today #MUNATL #UCL https://t.co/QSutW3zfsd