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#2 Sissoko/Winks vs Paul Pogba
With Eric Dier ruled out due to injury, the defensive midfield responsibility would lie on the shoulders of Moussa Sissoko and Harry Winks. The Frenchman can play as a right winger as well which gives Pochettino some versatility in the squad. Winks has been getting more game time recently after injuries to Dembele and Wanyama reduced the Argentine's option in the middle of the park.
Both of them would be up against a rejuvenated Paul Pogba who is gradually proving his worth at Manchester United. The last few games under Solskhaer were a testament of what Pogba is capable of, and he could have a massive say in this fixture as well.
Paul missed the FA Cup clash against Reading and would be fresh and fit for the Spurs game. The Frenchman has the luxury to move forward and showcase his creativity in the attacking third which is a dangerous sign for Pochettino and his men.
