AC Milan will be hoping to set aside the disappointment of losing the Super Coppa Italiana and foucs on the league as the Rossoneri look to get back into the Champions League reckoning spots.
After a bright start to the season with four victories in their opening five matches, Genoa has faltered with the Grifone winning just one of their next 14 league matches.
The host will be looking to start the first week of the new year with the win when they meet the Milan giants.
After a mini blip in form, the Rossoneri has finally started to rediscover their mojo at the right time as they look to leapfrog AS Roma into the fourth and last Champions League spot.
The first encounter between the sides ended with AC Milan winning 2-1 at the San Siro.
Leading goal scorer Kryzstof Piatek will be unavailable for Genoa with suspension while Sandro and Oscar Hiljemark are doubtful for the upcoming match.
AC MilanThe Ivorian will be missing out for AC Milan after receiving the marching orders against Juventus
Frank Kessie will be missing out after receiving the marching orders against Juventus in the Super Cup while Davide Calabria and Alessio Romagnoli will be missing for the Rossoneri after reaching the maximum limit of yellow cards.
Gonzalo Higuain is expected to miss out with the Argentine rumoured to be on the move to Chelsea.
Giacomo Bonaventura, Lucas Biglia and Mattia Caladara are still far from returning back from injury.
Genoa FC (3-5-2): Radu; Biraschi, Romero, Criscito; Rolon, Romulo, Lazovic, Hiljemark, Bessa; Kouame, Favilli.
AC Milan(4-3-3): Donnarumma; Abate, Zapata, Mussacchio, Rodriguez; Bakayako, Paqueta, Cahlanoglu; Castillejo, Cutrone, Suso