This will be the second meeting between the two sides this season after the Rovers claimed a comfortable 3-1 victory back in November’s reverse fixture.
After playing out two consecutive goalless draws against Huddersfield Town and Hull City in their previous two outings, Sheffield United returned to winning ways in style as they saw off Swansea City 4-0 last Saturday.
The Blades are now unbeaten in each of their last eight games, claiming five wins and three draws in that time.
This fine run of results has seen Sheffield United rise into playoff contention as they sit sixth in the EFL Championship table with 50 points from 31 games.
Meanwhile, Blackburn Rovers failed to find their feet last time out as they were held to an uneventful goalless draw at West Bromwich Albion.
They have now failed to taste victory in any of their last four games, claiming two draws and losing two since a 1-0 win over Middlesbrough on January 24.
For all their recent struggles, Blackburn Rovers are currently third in the league table, with 54 points from 32 games.
Sheffield United vs Blackburn Rovers Head-To-Head
Sheffield United boast a superior record in the history of this fixture, claiming 59 wins from the last 150 meetings between the sides. Blackburn Rovers have picked up 55 wins in that time, while 36 games have ended all square.
Sheffield United Form Guide: W-W-D-D-W
Blackburn Rovers Form Guide: W-D-L-L-D
Sheffield United vs Blackburn Rovers Team News
Sheffield United will be without the services of Rhian Brewster, Jayden Bogle, Ben Osborn, Enda Stevens, David McGoldrick and Jack O'Connell, who are all recuperating from injuries.
Injured: Rhian Brewster, David McGoldrick, Jack O'Connell, Ben Osborn, Enda Stevens, Jayden Bogle
Tayo Edun, Ian Poveda, Bradley Dack, Deyovaisio Zeefuik and Dilan Markanday are all recuperating from injuries and will sit out the game.
Injured: Tayo Edun, Ian Poveda, Bradley Dack, Deyovaisio Zeefuik, Dilan Markanday
Sheffield United vs Blackburn Rovers Predicted XI
Sheffield United Predicted XI (3-4-2-1): Wes Foderingham; Jack Robinson, John Egan, Chris Basham; Rhys Norrington-Davies, Conor Hourihane, Oliver Norwood, George Baldock; Iliman Ndiaye, Morgan Gibbs-White; Oli McBurnie
Blackburn Rovers Predicted XI (3-4-1-2): Thomas Kaminski; Darragh Lenihan, Jan van Hecke, Scott Wharton; Ryan Nyambe, Lewis Travis, Joe Rothwell, Ryan Giles; John Buckley; Reda Khadra, Sam Gallagher
Sheffield United vs Blackburn Rovers Prediction
Sheffield United have turned a corner in recent weeks and head into Wednesday’s game as one of the most in-form sides in the division. While taking on third-placed Blackburn Rovers can be a tough task for any side, we are tipping the Blades to come away with all three points.
Prediction: Sheffield United 2-1 Blackburn Rovers
Where does Mane rank in Paul Merson's 5 greatest Liverpool signings of the Klopp era? Click here