The hosts come into the game on the back of a 2-1 victory away to Burton Albion. Goals from Curtis Main and Harry Chapman gave Shrewsbury Town all three points.
Portsmouth were also 2-1 victors over Ipswich Town. Tom Naylor and Marcus Harness helped Pompey to a comeback victory at Fratton Park.
That win helped the Hampshire side climb up to eighth in the table. Shrewsbury Town are further below in 17th.
Shrewsbury Town vs Portsmouth Head-to-Head
This will be the 29th meeting between the sides. Portsmouth have 14 wins and four draws in previous games between the two sides, while Shrewsbury Town have 10 victories to their name.
Their most recent meeting came on matchday one of the current campaign when the two sides could not be separated in a goalless stalemate.
Shrewsbury Town are unbeaten in their last four league games, with two wins and two draws posted by the Shrews. Portsmouth, by contrast, have been in poorer form and have lost four of their last five league games.
Shrewsbury Town form guide: W-D-D-W-L
Portsmouth form guide (all competitions): W-L-L-L-L
Shrewsbury Town vs Portsmouth Team News
Defender Aaron Pierre is nearing a return to full fitness after two months out with a calf problem. Donald Love has also been sidelined with a groin injury but Josh Daniels has thrived in the right wing-back role in his absence.
There are no suspension worries for manager Steve Cotterill.
Injuries: Donald Love, Aaton Pierre
John Marquis (ankle) and Callum Johnson (calf) are in line for returns to full fitness and will be assessed ahead of the trip to Shrewsbury Town.
Alex Bass (broken leg) and Ellis Harrison (knee) have been ruled out for the rest of the season.
Winger Michael Jacobs recently made a return to fitness from a hamstring injury and was named on the bench for last weekend's visit of Ipswich Town.
There are no suspension concerns for manager Danny Colwey.
Injuries: Alex Bass, Ellis Harrison, John Marquis, Callum Johnson
Shrewsbury Town vs Portsmouth Predicted XI
Shrewsbury Town Predicted XI (3-5-2): Harry Burgoyne; Ro-Shaun Williams, Ethan Ebanks-Landell, Matthew Pennington; Nathaniel Ogbeta, Josh Vela, Sean Gross, David Davis, Joshua Daniels; Curtis Main, Harry Chapman
Portsmouth Predicted XI (4-4-2): Craig MacGillivray, Lee Brown, Sean Raggett, Jack Whatmough, James Bolton; Ronan Curtis, Andy Cannon, Tom Naylor, Marcus Harness; Ryan Williams, Jordy Hiwula-Mayifuila
Shrewsbury Town vs Portsmouth Prediction
The appointment of Danny Cowley has injected new life into Portsmouth and the players will be keen to keep their momentum going. Shrewsbury Town have also impressed in recent weeks which has seen them steer clear of the relegation zone.
The two sides have open styles of play which means that goals might be scored at both ends. We are predicting a share of the spoils in an entertaining fixture.
Prediction: Shrewsbury Town 1-1 Portsmouth