Porto are currently second in the league table, tallying 70 points from 30 games so far. Benfica are just four points and a spot behind them from the same number of matches played.
Benfica are coming off a routine 0-2 win against Tondela, a game which saw midfielders Pizzi and Everton score for the visitors in the first half. Jorge Jesus' men held on to the lead in the second half, earning a well-deserved three points.
Meanwhile, FC Porto played an entertaining game against FC Famalicao in their last Primeira Liga clash, winning 3-2 at home.
Anderson Silva's stoppage-time goal for Famalicao sent a wave of tension into the FC Porto camp. However, goals from Toni Martinez, Mehdi Teremi and Marko Grujic proved to be enough to secure victory for the home side.
SL Benfica vs FC Porto Head-to-Head
The two Primeira Liga giants have played a total of 57 games between them. FC Porto hold the bragging rights with 28 wins, while the Eagles have prevailed in 14 games. A total of 15 matches have ended in draws.
The last time the two sides met, Alejandro Grimaldo's strike in the early stages of the first half was quickly canceled out by Moussa Marega's goal.
Mehdi Teremi, who assisted Marega's goal, was sent off in the second half in a game that saw multiple players go into the referee's book.
SL Benfica's form guide in the Primeira Liga: W-L-W-W-W
FC Porto's form guide in the Primeira Liga: W-W-W-D-W
SL Benfica vs FC Porto Team News
Andre Almeida has missed most of the season with a cruciate ligament rupture and he remains out of action. Meanwhile, Andreas Samaris and Adel Taarabt are also out of contention for the hosts.
Jardel and Darwin Nunez will also be unavailable for selection due to undisclosed injuries.
Injured: Andre Almeida, Andreas Samaris, Adel Taarabt, Jardel, Darwin Nunez
Back-up goalkeeper Mouhamed Mbaye and centre-back Ivan Marcano remain sidelined for Porto but the visitors have an otherwise fully-fit squad to choose from.
Injured: Mouhamed Mbaye and Ivan Marcano
SL Benfica vs FC Porto Predicted XI
SL Benfica Predicted XI (4-4-2): Helton Leite; Gilberto, Lucas Verissimo, Jan Vertonghen, Alejandro Grimaldo; Rafa Silva, Pizzi, Gabriel Pires, Everton; Luca Waldschmidt, Haris Seferovic.
FC Porto Predicted XI (4-4-2): Agustin Marchesin; Jesus Corona, Chancel Mbemba, Pepe, Wilson Manafa; Chico Conceicao, Mateus Uribe, Marko Grujic, Otavio; Toni Martinez, Mehdi Taremi.
SL Benfica vs FC Porto Prediction
Both teams have been in a rich vein of form lately, winning four out of their last five league games.
The two managers are likely to go into the game with a cautious approach, which may result in a tedious stalemate in the O Classico.
Prediction: SL Benfica 0-0 FC Porto