#1 3-4-1-2

This is a slight variation of the previous formation. Higuain could partner Aguero in attack and leave Messi to find the pockets of spaces behind them in a floating role. Messi excels in a free role, roaming around in the final third.
A 3-4-1-2 lineup would provide a direct approach, having two men to aim at in the box. It could effectively pit the two strikers and the two wing-backs against the opposition back four. Di Maria and Salvio have the ability to track back, which will be vital as this system lacks any wingers.
Higuain and Aguero are world-class forwards but they have not played in tandem often for their country. They could be lethal if given the chance. If not from the first minute, this system can prove to be effective while chasing a goal.