Wycombe Wanderers host Tottenham Hotspur in an FA Cup fourth-round clash on Monday night.The cup represents another opportunity for Spurs to win a trophy this season. They are already in the final of the League Cup, where they will face Manchester City in April.Tottenham played eighth-tier Marine AFC in the third round of the FA Cup. The clash represented the biggest difference between two FA Cup opponents thus far in terms of the domestic league. Spurs won that game 5-0, with a hat-trick from Carlos Vinicius, and have picked up four points from two Premier League games since.Their draw against Fulham last week would have disappointed Jose Mourinho. With a huge Premier League clash against Liverpool coming up on Thursday night, he could well decide to rotate his side for this game.Wycombe Wanderers vs Tottenham Hotspur Head-to-HeadWycombe have faced Tottenham just once in the past, in an FA Cup thriller a few years ago. Wycombe took an early 2-0 lead but got pegged back to 2-2. However, they again managed to make it 3-2. Further goals from Dele Alli and Son Heung-Min late in the second half secured the win for Tottenham by the end of the game.✨ Our last @EmiratesFACup clash with @wwfcofficial was an absolute classic! ⏱️ 23: Spurs 0-1 Wycombe ⏱️ 36: Spurs 0-2 Wycombe ⚽ 60: Spurs 1-2 Wycombe ⚽ 64: Spurs 2-2 Wycombe ⏱️ 83: Spurs 2-3 Wycombe ⚽ 89: Spurs 3-3 Wycombe ⚽ 90+7: Spurs 4-3 Wycombe#THFC ⚪️ #COYS pic.twitter.com/gzUAwgL8kb— Tottenham Hotspur (@SpursOfficial) January 23, 2021Wycombe Wanderers form guide: W-L-W-L-DTottenham Hotspur form guide: W-D-W-W-WWycombe Wanderers vs Tottenham Hotspur Team NewsWycombe WanderersWycombe do not have any known injury concerns at the moment, and will be able to select their best team to face Spurs.Injured: NoneDoubtful: NoneSuspended: NoneTottenham HotspurSpurs could remain without the injured Giovani Lo Celso. Mourinho also mentioned that Dele Alli will miss this game due to a tendon injury.📋 ICYMI - The latest team news ahead of Monday's trip to Wycombe.#THFC ⚪️ #COYS— Tottenham Hotspur (@SpursOfficial) January 22, 2021Injured: Giovani Lo Celso, Dele AlliDoubtful: Serge AurierSuspended: NoneWycombe Wanderers vs Tottenham Hotspur Predicted XIWycombe Wanderers Predicted XI (4-5-1): Ryan Allsop; Jack Grimmer, Josh Knight, Ryan Tafazolli, Joe Jacobson; Curtis Thompson, Dominic Gape; David Wheeler, Daryl Horgan, Fred Onyedinma; Scott KashketTottenham Hotspur Predicted XI (4-2-3-1): Joe Hart; Matt Doherty, Davinson Sanchez, Joe Rodon, Ben Davies; Moussa Sissoko, Harry Winks; Gareth Bale, Erik Lamela, Lucas Moura; Carlos ViniciusWycombe Wanderers vs Tottenham Hotspur PredictionMourinho knows that the domestic cups present Tottenham's best opportunities to win trophies this season. Even though he is likely to make a couple of changes, it is unlikely to be a significantly weaker team. We are predicting a comfortable Tottenham win against Wycombe.Prediction: Wycombe Wanderers 0-2 Tottenham Hotspur