The holders have already sealed their place in the finals, having won thrice and drawn once from four games so far. They will aim to close out the qualifiers on a high.
They're at home to Botswana on the final matchday but first have the trip to Lusaka to deal with.
The Copper Bullets are languishing at the bottom of Group H with three defeats and just one win in their campaign so far.
They trail second-placed Zimbabwe by two points and another setback on Thursday would effectively end their hopes of playing in next year's championship.
Zambia won the prize in 2012, their first and only title so far, but have failed to qualify for the last two editions of the Afcon.
Zambia vs Algeria Head-To-Head
In 15 meetings between the sides, Zambia have won only four games against Algeria, and lost twice as many.
Their last clash ended in a win for the Desert Warriors, who thrashed the East African outfit 5-0 at home.
Zambia Form Guide (all competitions): L-W-D-D-L
Algeria Form Guide (all competitions): W-W-D-W-D
Zambia vs Algeria Team News
Milutin Sredojevic has named a massive 33-player squad for this month's double header, including RB Salzburg players Enock Mwepu and Patson Daka. Meanwhile, in-form striker Brian Mwila has also been recalled.
Evans Kangwa is the only notable absentee as the Arsenal Tula striker misses out.
Unavailable: Evans Kangwa
The Desert Warriors have some big names on their roster, including Riyad Mahrez, Ismael Bennacer, Sofiane Feghouli, Islam Slimani, and Ramy Bensebaini. Mahrez may be rested for this game and used in the next match against Botswana.
Bennacer is not expected to start the game against Zambia, with Mehdi Abeid possibly taking his place in midfield.
Nice's Youcef Atal is currently recovering from COVID-19, while Mohamed Fares withdrew with an injury.
Injured: Mohamed Fares
Unavailable: Youcef Atal
Zambia vs Algeria Predicted XI
Zambia (3-4-1-2): Cyril Chibwe; Tandi Mwape, Luka Banda, Adrian Chama; Amity Shamende, Kelvin Kapumbu, Gamphani Lungu, Bruce Masakanya; Kings Kangwa; Justin Shonga and Emmanuel Chabula.
Algeria (4-2-3-1): Rais M'Bolhi; Djamel Benlamri, Aissa Mandi, Mehdi Tahrat, Ramy Bensebaini; Adlene Guedioura, Mehdi Abeid; Harris Belkebla, Sofiane Feghouli, Rachid Ghezzal; Baghdad Bounedjah.
Zambia vs Algeria Prediction
Algeria have already secured their place in next year's finals, but that doesn't mean they won't take this match seriously.
Zambia have a challenge on their hands and might eke out a draw to keep their qualifying hopes alive.
Prediction: Zambia 2-2 Algeria