The hosts, who were handed an opening-day defeat, will be looking to quickly bounce back and get their campaign up and running.
Zambia were on the receiving end of a 3-1 defeat away to Ivory Coast in their group opener on Friday.
The Chipolopolo now return home where they are on a two-game unbeaten run, claiming one win and one draw in that time.
However, Zambia will fancy their chances of picking up their first win of the qualifiers as they take on an opposing side who they have beaten in each of the last two meetings between the teams.
Elsewhere, Comoros got their qualification campaign off to a flyer as they claimed a comfortable 2-0 win over Lesotho last time out.
They have now won three of their last four games across all competitions, with January’s 2-1 loss to Cameroon being the exception.
While Comoros will look to pick up a third successive victory, they have managed just one win from their last six away games, losing four and claiming one draw in that time.
Zambia vs Comoros Head-To-Head
This will be just the third meeting between the sides, with Zambia winning both of their previous two encounters.
Zambia Form Guide: L-L-W-D-L
Comoros Form Guide: W-W-L-W-L
Zambia vs Comoros Team News
Zambia came out unscathed against Ivory Coast last time out and boasts a clean bill of health and no suspension concerns.
Off the back of a dominant win over Lesotho, manager Amir Abdou could name an unchanged starting lineup on Tuesday. There are no injuries or suspension concerns for Comoros.
Zambia vs Comoros Predicted XI
Zambia Predicted XI (4-3-3): Toaster Nsabata; Lubambo Musonda, Frankie Musonda, Tandi Mwape, Rodrick Kabwe; Lameck Banda, Enock Mwepu, Evans Kangwa; Patson Daka, Prince Mumba, Fashion Sakala
Comoros Predicted XI (4-2-3-1): Ali Ahamada; Mohamed Youssouf, Younn Zahary, Abdel Hakim Abdallah, Saïd Bakari; Fouad Bachirou, Rafidine Abdullah; Faïz Selemani, Youssouf M'Changama, Kassim M'Dahoma; El Fardou Ben
Zambia vs Comoros Prediction
Despite their disappointing opening-day performance, Zambia head into the game as slight favourites to come away with all three points. While we expect Comoros to put up a fight, we are backing the hosts to make amends for Friday’s loss and pick up their first win of the qualifiers.
Prediction: Zambia 2-1 Comoros