The list of riders taking part in the 2019 MotoGP world championship.
| Rider | Bike |
| Marc Márquez | Honda |
| Jorge Lorenzo | Honda |
| Andrea Dovizioso | Ducati |
| Danilo Petrucci | Ducati |
| Karel Abraham | Ducati |
| Tito Rabat | Ducati |
| Cal Crutchlow | Honda |
| Takaaki Nakagami | Honda |
| Álex Rins | Suzuki |
| Joan Mir | Suzuki |
| Valentino Rossi | Yamaha |
| Maverick Viñales | Yamaha |
| Franco Morbidelli | Yamaha |
| Fabio Quartararo | Yamaha |
| Pol Espargaró | KTM |
| Johann Zarco | KTM |
| Miguel Oliveira | KTM |
| Hafizh Syahrin | KTM |
| Aleix Espargaró | Aprilia |
| Bradley Smith | Aprilia |
| Andrea Iannone | Aprilia |
| Jack Miller | Ducati |
| Francesco Bagnaia | Ducati |
