Best NFL DFS Picks for Thursday Night Football: 49ers vs. Seahawks- December 15

The San Francisco 49ers are as hot as any team in the NFL. The 49ers take their momentum to the Pacific Northwest to take on their bitter NFC West rivals, the Seattle Seahawks. The 49ers appear to be legitimate NFL title contenders.

The Seattle Seahawks remain in the thick of the playoff hunt and need to string victories together to reach the postseason.

Best quarterback picks

Cash Games: Brock Purdy, QB, San Francisco 49ers (DraftKings $14.4K, FanDuel $15K)

Brock Purdy looked sensational last weekend. What does the 7th-round rookie have in store for an encore?

Tournaments: Geno Smith, QB, Seattle Seahawks (Draftkings $15.9K, FanDuel $14.5K)

Geno Smith has played great all season long, but on Thursday, Smith faces a challenge against an All-World 49ers' defense. No one will have faith in Geno Smith, which means you can gain leverage on the field.

$1,000 No Sweat First Bet with FanDuel

Best running back picks

Cash Games: Christian McCaffrey, RB, San Francisco 49ers (DraftKings $17.1K, FanDuel $17.5K)

Christian McCaffrey remains one of the most dynamic talents in the NFL, as the 49ers are using C-Mac properly in their offense as a runner and receiver. C-Mac has developed early chemistry with new starting QB Brock Purdy.

Tournament: Kenneth Walker III, RB, Seattle Seahawks (DraftKings $11.4K, FanDuel $12.5K)

When healthy, Kenneth Walker III is one of the best pure runners in the NFL. Walker has been better than advertised coming out of Michigan State. The Seahawks want to design their game plan to focus on their rushing attack. Even in one of the toughest matchups, against the San Francisco 49ers' dominant front seven, Kenneth Walker III makes a solid RB1.

Wide receivers and tight ends

Cash Games: Brandon Aiyuk, WR, San Francisco 49ers (DraftKings $13.2K, FanDuel $13K)

Brandon Aiyuk remains the 49ers' top downfield threat in the passing game. Aiyuk does bring versatility to the table, but his ability to make big plays down the field stands out. He will overwhelm Seattle's defensive backs and should be a standout performer this week.

Tournament: George Kittle, TE, San Francisco 49ers (DraftKings $12K, FanDuel $10.5K)

With Deebo Samuel missing several weeks with a high ankle sprain, which 49ers' pass-catcher will benefit the most? QB Brock Purdy trusts RB Christian McCaffrey, but his involvement as a pass-catcher out of the backfield is locked in. George Kittle should see additional work in the intermediate area where Deebo Samuel worked.