New Orleans Saints vs. Arizona Cardinals Prediction, Odds, Line, Spread, and Picks - October 20 | 2022 NFL Football Season

Arizona Cardinals v Seattle Seahawks
New Orleans Saints vs. Arizona Cardinals

The Arizona Cardinals will be hosting the New Orleans Saints on Thursday. Both teams come in at 2-4, and they'll look to get back on track tonight. Arizona lost 19-9 last week to the Seahawks in Seattle, but they'll need their offense to start showing up. New Orleans lost last week at home to Cincinnati, but their run game has looked really good recently, which could be significant tonight.

New Orleans Saints vs. Arizona Cardinals Match Details

Fixture: New Orleans Saints @ Arizona Cardinals

Date & Time: Thursday, October 20, 8:15 p.m. EDT

Venue: State Farm Stadium, Glendale, Arizona

New Orleans Saints vs. Arizona Cardinals Betting Odds

TeamSpreadOver/UnderMoney Line
New Orleans Saints+2.5 (-110)Over 43.5 (-110)+115
Arizona Cardinals-2.5 (-110)Under 43.5 (-110)-135

New Orleans Saints vs. Arizona Cardinals Key Stats

The Saints' Alvin Kamara has missed two games due to injury, but his previous two performances have been excellent since returning. He's now up to 4.6 yards per carry, right in line with his career average. The Saints have also utilized Taysom Hill, who can play multiple positions, including QB, as a runner, and he's already accumulated 267 rushing yards on just 26 attempts, good for an average of 10.3 yards per carry. New Orleans hasn't named a starting QB for this matchup, but both Jameis Winston and backup Andy Dalton have been up and down. The Cardinals don't have a great passing defense, but they have done a decent job stopping the run, and they'll need to find a way to stuff Kamara and the Saints running game tonight.

Arizona's franchise quarterback Kyler Murray has had a rough year after a pretty solid 2021 season. Murray is averaging just 5.8 yards per passing attempt, way below his career mark of 7.1. He's really only had two good games out of six so far, and he'll need to take advantage of a Saints defense that surrenders the fourth-most points per game. New Orleans has just one interception as a team, a stat that should help Murray, who has thrown a pick in each of his last three games. The former #1 pick will also be glad to have DeAndre Hopkins back, who has been Murray's favorite target when healthy. He's caught 159 passes in 26 games in a Cardinals uniform, so we'll see how much he can contribute tonight.

New Orleans Saints vs. Arizona Cardinals Betting Prediction

With New Orleans' quarterback situation still undecided, the advantage goes to Arizona. With Hopkins returning too, this should help the Cardinals a lot, even if he isn't 100%, as he'll command a lot of attention from the Saints' defense. Arizona has struggled badly at home, losing eight in a row and covering just one of these eight. Still, they should break this streak tonight against a subpar New Orleans defense and an inconsistent passing attack.

Prediction: Cardinals -2.5 (-110)

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