Saints vs 49ers: Who Will Win? Betting Prediction, Odds, Line, Spread, and Picks

The San Francisco 49ers will be at home to face the New Orleans Saints on Sunday. The Niners are up to 6-4, and they're now the joint-leaders in the NFC West. Last week, they knocked off the Cardinals 38-10 in Mexico City, the 49ers' third consecutive win. For New Orleans, they defeated the Rams 27-20 at home, snapping a two-game skid to move to 4-7. Despite the difference in records, both teams are in the thick of division title races, and they'll look to gain some momentum Sunday.

New Orleans Saints vs. San Francisco 49ers Match Details

Fixture: New Orleans Saints @ San Francisco 49ers

Date & Time: Sunday, November 27, 4:25 p.m. EDT

Venue: Levi's Stadium, Santa Clara, California

New Orleans Saints vs. San Francisco 49ers Betting Odds

Team	Spread	Over/Under	Money Line
New Orleans Saints	+9.0 (-112)	Over 43 (-109)	+360
San Francisco 49ers	-9.0 (-109)	Under 43 (-112)	-435

Odds Courtesy of Betrivers Sportsbook

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New Orleans Saints vs. San Francisco 49ers Key Stats

The 49ers have one of the better defenses in the league, but last week their offense exploded for 38 points and 387 total yards. QB Jimmy Garoppolo tossed a season-high four TDs in the win, and on the year, he's up to 15, to just four picks. Garoppolo took over for the injured Trey Lance back in September, and he's filled in nicely. His main targets, Brandon Aiyuk and George Kittle, are pretty reliable, and Deebo Samuel, who is listed as questionable, is also a great weapon to have. The Niners made a huge trade to acquire All-Pro running back Christian McCaffrey, and so far, he's been great for his new team. Look for McCaffrey to be active again both rushing-wise and as a pass catcher on Sunday, as the 49ers' offense looks to build off their great Monday Night performance.

New Orleans has stuck with QB Andy Dalton despite Jameis Winston, who started the year under center, being back in practice for a few weeks now. Dalton has been solid in his eight games played, as he's tallied 14 passing TDs and seven interceptions, and he's up at 7.5 yards per passing attempt. Dalton, along with Alvin Kamara, will try to carry the offense as the receiving corps outside of standout Chris Olave has been unreliable. The 49ers have a great pass rush, and they also allow the fewest rushing yards per game and fewest points overall, so the Saints offense will need to get creative on Sunday if they are to end the 49ers' wins streak.

New Orleans Saints vs. San Francisco 49ers Betting Prediction

The Saints' offense finally showed up last week versus the Rams, but they might struggle to get on the board on Sunday. San Francisco has looked really comfortable over the past few weeks, and dating back to last year, and they're 10-2 against the spread in their previous 12 versus NFC opponents. Ultimately, the Niners are rolling right now and should be able to win by double digits at home on Sunday.