Blue Jays vs Cardinals: Game 1 prediction, odds, injuries, and picks

The Toronto Blue Jays and St. Louis Cardinals are set to begin a three-game interleague series on Monday night at Busch Stadium. This is a matchup of two teams that have been playing well this season, and Game 1 should be a great matchup.

Toronto brings a 35-30 record into the series opener, while St. Louis is now sitting at 36-29 on the year. Here is a look at the odds for the series opener, and some predictions to make.

Blue Jays vs. Cardinals prediction

Jose Berrios is pitching today - Source: Imagn

Jose Berrios is set to start for the Toronto Blue Jays in this game, and he has gone 2-2 with a 3.67 ERA so far this season. Pitching has not been an area of strength for this team, but Berrios should be able to keep his team in the game.

George Springer leads the Blue Jays with 10 home runs, and Bo Bichette has 37 RBIs. Toronto has been extremely streaky on offense, and they still need to be more consistent.

Lars Nootbar leads the Cardinals with eight home runs this season, and this is a team without much power. St. Louis continues to come up with clutch hits, and that will be something to monitor in this matchup.

Andre Pallante starts for the Cardinals on Monday night, and he has gone 4-3 with a 4.91 ERA so far this season. Look for Pallante to pitch well enough to deliver the Cardinals a win in this matchup.

Prediction: St. Louis Cardinals 5, Toronto Blue Jays 4

Blue Jays vs. Cardinals odds

Money Line: Toronto Blue Jays -115, St. Louis Cardinals -105

Run Spread: Blue Jays -1.5 (+145), Cardinals +1.5 (-175)

Total Runs: Over 8.5 (-105), Under 8.5 (-115)

Blue Jays vs. Cardinals injuries

Toronto Blue Jays injury report:

Max Scherzer (RHP): 60-Day IL (Right thumb inflammation)

Nick Sandlin (RHP): 15-Day IL (Right lat strain)

Daulton Varsho (OF): TBD (Left hamstring strain)

Anthony Santander (OF): 10-Day IL (Left shoulder inflammation)

Yimi Garcia (RHP): 15-Day IL (Right shoulder impingement)

Ryan Burr (RHP): 60-Day IL (Right shoulder inflammation)

Alek Manoah (RHP): 60-Day IL (Right UCL surgery)

St. Louis Cardinals injury report:

Jordan Walker (OF): 10-Day IL (Left wrist inflammation)

Matthew Liberatore (LHP): TBD (Fatigue-related issues)

Zack Thompson (LHP): 60-Day IL (Left lat strain)

Blue Jays vs. Cardinals picks

St. Louis has been playing great baseball lately, so focusing on the Cardinals when making picks in this matchup is the way to go.

Money Line: St. Louis Cardinals -105

Run Spread: Cardinals +1.5 (-175)

Total Runs: Over 8.5 (-105)

About the author

Ryan Burks is a baseball journalist at Sportskeeda with over 7 years of experience in the field, writing for publications such as Knup Sports. Ryan graduated from Elmhurst College in 2009 with a degree in Communications.

Ryan is a huge Chicago Cubs fan and enjoys their storied history and traditions. His favorite sporting moment was when the Cubs won the 2016 World Series, breaking a championship drought that dated back to 1908.

His favorite player was Ken Griffey Jr., as Ryan grew up during his prime and he was the coolest player in league history. Greg Maddux also deserves a mention, as he was truly amazing on the mound.

When not working or watching sports, Ryan coaches basketball and baseball, loves fishing, and spends time with his family.

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Edited by Nadim El Kak

Blue Jays vs Cardinals: Game 1 prediction, odds, injuries, and picks - June 9, 2025